| The protective role of glutathione in silver induced toxicity in blood components. | |
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MedLine Citation:
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PMID: 21454159 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Silver Nitrate (AgNo(3)) effect on the status of reduced glutathione (GSH), the major non-protein thiol in blood components were examined using freshly isolated plasma and cytosolic fraction of whole blood of healthy human volunteer. AgNo(3) had significant effects on GSH contents reduction in plasma and cytosolic fraction of blood. Effect or reduction in GSH content was more pronounced or significant at AgNo(3) concentration with time intervals (minutes to hours). Depletion of GSH in plasma and cytosolic fraction of blood by the addition of AgNo(3) indicates that AgNo(3) penetrated the cell membrane and reacted with GSH, depleted its contents mostly due to oxidation of reduced Glutathione (GSH) to glutathione disulphide (GSSG) 2 GSH - GSSG + 2H(+) or likely that AgNo(3) after penetration formed a Silver-Glutathione (Ag-SG) complex. Time dependent effect of AgNo(3) on the chemical status of glutathione was discussed in vitro in this paper which in principle presents the model of in vivo reaction, which will be the precise indirect impression of AgNo(3) detoxification resulting by the interaction with GSH. |
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Authors:
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Haroon Khan; Muhammad Farid Khan; Asimur Rehman; Syed Umer Jan; Naseem Ullah |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pakistan journal of pharmaceutical sciences Volume: 24 ISSN: 1011-601X ISO Abbreviation: Pak J Pharm Sci Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9426356 Medline TA: Pak J Pharm Sci Country: Pakistan |
Other Details:
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Languages: eng Pagination: 123-8 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gomal University, D.I. Khan, Pakistan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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