| The protective role of glucose on ischemic-reperfused hearts: effect of dietary fats. | |
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MedLine Citation:
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PMID: 1749006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The dietary polyunsaturated fatty acids are well known to promote the cardiac output and to protect the myocardium against arrhythmias. The exogenous glucose is generally considered as a protective agent against arrhythmias resulting from ischemia and reperfusion. But the effects of dietary fats, which also influence arrhythmias, on this beneficial effect of glucose has not been yet considered. We have studied the effects of a 7 days diet with or without polyunsaturated fatty acids on the cardiac performance and arrhythmias of isolated rat hearts, perfused with saline containing either glucose 5.5 mM or 11 mM. Acute regional ischemia was produced by ligature of the left main coronary artery with subsequent release to achieve reperfusion for some hearts. Previously, our results showed that the dietary polyunsaturated fatty acids led to an enhancement of the cardiac performance and to a decreased susceptibility to arrhythmias. The present data showed that the protective action of the exogenous glucose appeared to be dependent of the dietary lipid profile. Dietary polyunsaturated fatty acids increase cardiac performance under ischemia and decrease ventricular arrhythmias' occurrence under ischemia and on reperfusion. It might be related to endogenous substrate utilization and exogenous glucose availability which was influenced by the coronary flow. |
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Authors:
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D Moreau; J M Chardigny |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of molecular and cellular cardiology Volume: 23 ISSN: 0022-2828 ISO Abbreviation: J. Mol. Cell. Cardiol. Publication Date: 1991 Oct |
Date Detail:
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Created Date: 1992-01-21 Completed Date: 1992-01-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0262322 Medline TA: J Mol Cell Cardiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1165-76 Citation Subset: IM |
Affiliation:
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Laboratoire de Physiologie, Faculté de Médecine 7 Boulevard Jeanne d'Arc, Dijon. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arrhythmias, Cardiac / prevention & control* Cardiac Output / drug effects Coronary Circulation / drug effects Coronary Disease / physiopathology* Dietary Fats, Unsaturated / administration & dosage* Glucose / pharmacology* Glycogen / metabolism Heart Rate / drug effects Male Myocardium / metabolism Oxygen Consumption / drug effects Phospholipids / metabolism Rats Rats, Inbred Strains Reperfusion Injury / prevention & control* Triglycerides / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats, Unsaturated; 0/Phospholipids; 0/Triglycerides; 50-99-7/Glucose; 9005-79-2/Glycogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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