Document Detail


The protective potency of probiotic bacteria and their microbial products against enteric infections-review.
MedLine Citation:
PMID:  18661289     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The intestinal environment accommodates a wide range of contents ranging from harmless beneficial dietary and microbial flora to harmful pathogenic bacteria. This has resulted in the development of highly adapted epithelial cells lining the intestine. This adaptation involves the potential of crypt cells to proliferate and to constantly replace villous cells that are lost due to maturity or death. As a result, the normal intestinal epithelial integrity and functions are maintained. This phenomenon is eminent in intestinal defense whereby the intestinal epithelial cells serve as a physical barrier against luminal agents. The protection against agents in the gut lumen can only be effective if the epithelium is intact. Restitution of the damaged epithelium is therefore crucial in this type of defense.
Authors:
J F J G Koninkx; J J Malago
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-07-27
Journal Detail:
Title:  Folia microbiologica     Volume:  53     ISSN:  0015-5632     ISO Abbreviation:  Folia Microbiol. (Praha)     Publication Date:  2008  
Date Detail:
Created Date:  2008-07-28     Completed Date:  2008-10-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376757     Medline TA:  Folia Microbiol (Praha)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  189-94     Citation Subset:  IM    
Affiliation:
Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, 3508 TD, Utrecht, The Netherlands. J.Koninkx@vet.uu.nl
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MeSH Terms
Descriptor/Qualifier:
Antibiosis*
Bacteria* / growth & development,  pathogenicity
Bacterial Infections / microbiology,  prevention & control*
Caco-2 Cells
Epithelial Cells / immunology,  metabolism,  microbiology
Gastrointestinal Diseases / microbiology,  prevention & control*
Heat-Shock Proteins / metabolism
Humans
Intestines / cytology,  immunology,  microbiology
Probiotics*
Chemical
Reg. No./Substance:
0/Heat-Shock Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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