| The protective effects of hyperimmune anti-murine cytomegalovirus antiserum against lethal viral challenge: the case for passive-active immunization. | |
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MedLine Citation:
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PMID: 3004792 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The administration of 0.2 ml of hyperimmune anti-mouse cytomegalovirus (CMV) antiserum intraperitoneally (ip) or intravenously provided complete protection against lethal challenge (10(5.8) PFU ip) with murine CMV. Antiserum protection was complete when the antiserum was administered as long as 24 hr after viral challenge. The administration of antiserum had little effect on the titers of virus in the organs of these animals. Ammonium sulfate-treated antiserum provided similar complete protection. Animals rechallenged with 10(6)-10(6.5) PFU of murine CMV 1 month after initial challenge, at a time when the administrated antiserum was no longer detectable, all survived. We conclude that hyperimmune antiserum can provide significant protection against otherwise lethal murine CMV infection, that the protecting material lies within the immunoglobulin fraction, and that long-term immunity results from the combined exposure to virus and antiserum. Such passive-active protection could be useful in protecting against human CMV infection. |
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Authors:
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R H Rubin; E J Wilson; L V Barrett; D N Medearis |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Clinical immunology and immunopathology Volume: 39 ISSN: 0090-1229 ISO Abbreviation: Clin. Immunol. Immunopathol. Publication Date: 1986 Apr |
Date Detail:
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Created Date: 1986-04-24 Completed Date: 1986-04-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0356637 Medline TA: Clin Immunol Immunopathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 151-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Viral / analysis Cytomegalovirus / immunology, isolation & purification Cytomegalovirus Infections / immunology* Female Fluorescent Antibody Technique Heart / microbiology Immune Sera* Immunity, Active Immunization* Immunization, Passive* Liver / microbiology Mice Mice, Inbred BALB C Salivary Glands / microbiology Spleen / microbiology |
| Grant Support | |
ID/Acronym/Agency:
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HL18646/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral; 0/Immune Sera |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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