| The protective effects of exercise and phosphoinositide 3-kinase (p110alpha) in the failing heart. | |
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MedLine Citation:
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PMID: 19175355 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite the development of a wide range of therapies, heart failure remains a leading cause of death in Western society. New therapies are needed to help combat this debilitating condition. Exercise is becoming an increasingly important feature of rehabilitation programmes for patients with heart failure. Before the 1980s, patients with heart failure were advised not to exercise as it was thought that exercise would increase the risk of a cardiac event (such as myocardial infarction). However, in recent years both aerobic and resistance training have been shown to be safe and beneficial for patients with heart failure, improving exercise tolerance and quality of life, and preventing muscular deconditioning. The molecular mechanisms responsible for exercise-induced cardioprotection are yet to be elucidated, however studies in transgenic mice have identified PI3K(p110alpha) (phosphoinositide 3-kinase p110alpha) as a likely mediator. PI3K(p110alpha) is a lipid kinase which is activated in the heart during chronic exercise training, and is important for maintaining heart structure and function in various pathological settings. In the present review the protective effects of PI3K(p110alpha) in the failing heart and its potential as a therapeutic strategy for the treatment of heart failure is discussed. |
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Authors:
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Kate L Owen; Lynette Pretorius; Julie R McMullen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Clinical science (London, England : 1979) Volume: 116 ISSN: 1470-8736 ISO Abbreviation: Clin. Sci. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-01-29 Completed Date: 2009-04-02 Revised Date: 2009-08-14 |
Medline Journal Info:
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Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: England |
Other Details:
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Languages: eng Pagination: 365-75 Citation Subset: IM |
Affiliation:
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Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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1-Phosphatidylinositol 3-Kinase
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physiology* Animals Cardiotonic Agents / therapeutic use Enzyme Activation / physiology Exercise* Heart Failure / drug therapy, enzymology, rehabilitation* Humans Mice Mice, Transgenic Ventricular Remodeling / physiology |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; EC 2.7.1.137/1-Phosphatidylinositol 3-Kinase; EC 2.7.1.137/PIK3CB protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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