| The protective effect of supplemental calcium on colonic permeability depends on a calcium phosphate-induced increase in luminal buffering capacity. | |
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MedLine Citation:
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PMID: 21851756 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An increased intestinal permeability is associated with several diseases. Previously, we have shown that dietary Ca decreases colonic permeability in rats. This might be explained by a calcium-phosphate-induced increase in luminal buffering capacity, which protects against an acidic pH due to microbial fermentation. Therefore, we investigated whether dietary phosphate is a co-player in the effect of Ca on permeability. Rats were fed a humanised low-Ca diet, or a similar diet supplemented with Ca and containing either high, medium or low phosphate concentrations. Chromium-EDTA was added as an inert dietary intestinal permeability marker. After dietary adaptation, short-chain fructo-oligosaccharides (scFOS) were added to all diets to stimulate fermentation, acidify the colonic contents and induce an increase in permeability. Dietary Ca prevented the scFOS-induced increase in intestinal permeability in rats fed medium- and high-phosphate diets but not in those fed the low-phosphate diet. This was associated with higher faecal water cytotoxicity and higher caecal lactate levels in the latter group. Moreover, food intake and body weight during scFOS supplementation were adversely affected by the low-phosphate diet. Importantly, luminal buffering capacity was higher in rats fed the medium- and high-phosphate diets compared with those fed the low-phosphate diet. The protective effect of dietary Ca on intestinal permeability is impaired if dietary phosphate is low. This is associated with a calcium phosphate-induced increase in luminal buffering capacity. Dragging phosphate into the colon and thereby increasing the colonic phosphate concentration is at least part of the mechanism behind the protective effect of Ca on intestinal permeability. |
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Authors:
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Marloes A A Schepens; Sandra J M ten Bruggencate; Arjan J Schonewille; Robert-Jan M Brummer; Roelof van der Meer; Ingeborg M J Bovee-Oudenhoven |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-08-19 |
Journal Detail:
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Title: The British journal of nutrition Volume: 107 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-05-07 Completed Date: 2012-07-10 Revised Date: 2013-04-05 |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 950-6 Citation Subset: IM |
Affiliation:
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TI Food and Nutrition, PO Box 557, 6700 AN Wageningen, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Buffers Calcium Phosphates / metabolism Calcium, Dietary / administration & dosage* Cecum / drug effects, metabolism Colon / drug effects*, physiology* Dietary Carbohydrates / administration & dosage, metabolism Fermentation Lactic Acid / metabolism Male Oligosaccharides / administration & dosage, metabolism Permeability / drug effects Phosphates / administration & dosage, metabolism Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Buffers; 0/Calcium Phosphates; 0/Calcium, Dietary; 0/Dietary Carbohydrates; 0/Oligosaccharides; 0/Phosphates; 50-21-5/Lactic Acid; 97Z1WI3NDX/calcium phosphate |
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