Document Detail


The protective effect of lipoxygenase inhibitor FLM 5011 on mitochondria ultrastructure of ischemic and reperfused cardiomyocytes.
MedLine Citation:
PMID:  10334466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipoxygenase inhibitor FLM 5011 was used in experimental ischemia and reperfusion with dogs to investigate its ultrastructure-preserving effects on the mitochondria of myocardium. Ischemic and non-ischemic areas of the heart were ultrastructural-morphometric analysed, which revealed that FLM 5011 was able to diminish ischemic damage especially of mitochondria. The protective effects on mitochondria consisted mainly in reduction of defective intramitochondrial areas and in excellent protection of the structural integrity of cristae and matrix. The injury of mitochondria by ischemia/reperfusion in unprotected condition was partly more pronounced in the non-ischemic than in the ischemic area of the hearts probably caused by compensatory overload of the residual myocardium.
Authors:
G Fitzl; D Winkler; G Wassilev; K Welt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie     Volume:  51     ISSN:  0940-2993     ISO Abbreviation:  Exp. Toxicol. Pathol.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-06-25     Completed Date:  1999-06-25     Revised Date:  2006-10-30    
Medline Journal Info:
Nlm Unique ID:  9208920     Medline TA:  Exp Toxicol Pathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  245-53     Citation Subset:  IM    
Affiliation:
Institute of Anatomy, University of Leipzig, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Data Interpretation, Statistical
Dogs
Female
Lauric Acids*
Lipoxygenase Inhibitors / pharmacology*
Male
Microscopy, Electron
Mitochondria / drug effects*,  pathology,  ultrastructure
Myocardial Reperfusion Injury / prevention & control*
Myocardium / cytology,  pathology,  ultrastructure
Oximes*
Thoracotomy
Chemical
Reg. No./Substance:
0/Lauric Acids; 0/Lipoxygenase Inhibitors; 0/Oximes; 105634-48-8/FLM 5011

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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