| The protective effect of dl-tetrahydropalmatine against the development of amygdala kindling seizures in rats. | |
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MedLine Citation:
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PMID: 11852175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of dl-tetrahydropalmatine (THP), an active component isolated from a Chinese herbal medicine corydalis, was tested on the development of electrically kindled amygdala. The seizure activity was quantified by a ultrasonic system for vertical motion measurements. Intraperitoneal injection of THP (20 or 30 mg kg(-1)) 30 min before applying the daily kindling stimulus prevented the development of the kindling process. The behavioral seizure score and the motion responses which normally develop during electrical kindling were reduced below their initial values. The results suggest that THP is a very effective antiepileptogenic and anticonvulsant agent when applied to electrically kindled rats. |
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Authors:
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Mao-Tsun Lin; Jhi-Joung Wang; Ming-Shing Young |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience letters Volume: 320 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-03-07 Completed Date: 2002-04-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 113-6 Citation Subset: IM |
Affiliation:
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Department of Medical Research, Chi-Mei Medical Center, Yung-Kang City, Tainan Hsien 710, Taiwan. mtlin@ym.edu.tw |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amygdala
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drug effects*,
physiology Animals Anticonvulsants / pharmacology* Behavior, Animal / drug effects, physiology Berberine Alkaloids / pharmacology* Drugs, Chinese Herbal / pharmacology* Electronics, Medical / instrumentation, methods Epilepsy / drug therapy*, metabolism, physiopathology Kindling, Neurologic / drug effects*, physiology Male Motor Activity / drug effects, physiology Neural Inhibition / drug effects, physiology Neurotransmitter Agents / metabolism Rats Rats, Sprague-Dawley Synaptic Transmission / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Berberine Alkaloids; 0/Drugs, Chinese Herbal; 0/Neurotransmitter Agents; 10097-84-4/tetrahydropalmatine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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