Document Detail


The protective effect of breast feeding in relation to sudden infant death syndrome (SIDS): III. Detection of IgA antibodies in human milk that bind to bacterial toxins implicated in SIDS.
MedLine Citation:
PMID:  10443506     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two toxin-producing bacteria implicated in sudden infant death syndrome (SIDS) are Staphylococcus aureus and Clostridium perfringens. Epidemiological studies have shown that breast feeding reduces an infant's risk of SIDS. This protective effect could be due partly to IgA antibodies to these toxins in human milk. The aim of this work was to use a quantitative ELISA to determine levels of IgA antibodies that bound to toxic shock syndrome toxin (TSST-1), staphylococcal enterotoxin C (SEC) and C. perfringens enterotoxin A (CEA) in individual samples of human milk. All samples of milk tested contained IgA antibodies that bound to the bacterial toxins. For individual samples, IgA bound to TSST-1, SEC and CEA were in the range of 900-3100 ng ml(-1), 1000-3600 ng ml(-1) and 1000-4300 ng ml(-1) respectively. Isolation of S. aureus from mothers donating breast milk samples was used to determine if the presence of bacteria affected IgA levels which bound TSST-1 and SEC. For 3/5 samples with levels above the upper limit of the standard deviation (2375 ng ml(-1)) for IgA bound to TSST-1, S. aureus was isolated from the mother whilst 4/5 samples found to contain levels above the upper limit of the standard deviation (2627 ng ml(-1)) for IgA bound to SEC, had S. aureus isolated from the mother. In conclusion, if bacterial toxins do play a role in precipitating a SIDS death, the presence of IgA antibodies to toxins in breast milk, but not in infant formula, might contribute to the protective effect of breast feeding in relation to SIDS.
Authors:
A E Gordon; A T Saadi; D A MacKenzie; N Molony; V S James; D M Weir; A Busuttil; C C Blackwell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEMS immunology and medical microbiology     Volume:  25     ISSN:  0928-8244     ISO Abbreviation:  FEMS Immunol. Med. Microbiol.     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-10-14     Completed Date:  1999-10-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9315554     Medline TA:  FEMS Immunol Med Microbiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  175-82     Citation Subset:  IM    
Affiliation:
Department of Medical Microbiology, The Medical School, University of Edinburgh, UK. gordon@srv1.med.ed.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Antibodies, Bacterial / analysis,  immunology
Bacterial Toxins*
Breast Feeding*
Clostridium perfringens / immunology,  metabolism
Enterotoxins / immunology*
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin A / analysis*,  immunology
Infant
Infant Food
Infant, Newborn
Milk, Human / immunology*
Nose / microbiology
Pharynx / microbiology
Staphylococcus aureus / immunology,  isolation & purification,  metabolism
Sudden Infant Death / prevention & control*
Superantigens*
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Bacterial Toxins; 0/Enterotoxins; 0/Immunoglobulin A; 0/Superantigens; 0/enterotoxin F, Staphylococcal; 0/enterotoxin, Clostridium; 39424-54-9/enterotoxin C, staphylococcal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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