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The protective effect of amifostine on ultraviolet B-exposed xeroderma pigmentosum mice.
MedLine Citation:
PMID:  22276030     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Amifostine is a pharmaceutical agent that is used clinically to counteract the side-effects of chemotherapy and radiotherapy. It acts as a free radical scavenger that protects against harmful DNA cross-linking. The purpose of this study was to determine the effect of amifostine on the development of skin cancer in xeroderma pigmentosum (XP) mice exposed to ultraviolet B radiation (UVB).
METHODS: Twenty-five XP mice were equally divided into five groups. Group 1 (control) received no amifostine and no UVB exposure. Group 2 also received no amifostine, but was exposed to UVB at a dose of 200 mJ/cm(2) every other day. The remaining groups were subjected to the same irradiation, but were given amifostine at a dose of 50 mg/kg (group 3), 100 mg/kg (group 4), or 200 mg/kg (group 5) immediately prior to each exposure.
RESULTS: No tumours were seen in the control group. The animals in group 2 (no amifostine) developed squamous cell carcinoma (SCC) at 3.5-4.5 months (mean 3.9 months). Groups 3 and 4 (low- and medium-dose amifostine) developed SCC at 4.0-7.0 months (mean 5.3 months), representing a statistically significant delay in tumour presentation (p = 0.04). An even greater delay was seen in group 5 (high-dose amifostine), which developed SCC at 7.0-9.0 months (mean 8.5 months, p < 0.001 versus groups 3 and 4). Ocular keratitis developed in all animals except the unexposed controls and the high-dose treatment group.
CONCLUSION: Treatment with amifostine significantly delays the onset of skin cancer and prevents ocular keratitis in UVB-exposed XP mice.
Sl Henry; D Christiansen; Fr Kazmier; Cl Besch-Williford; Mj Concannon
Publication Detail:
Type:  Journal Article     Date:  2010-09-22
Journal Detail:
Title:  Ecancermedicalscience     Volume:  4     ISSN:  1754-6605     ISO Abbreviation:  Ecancermedicalscience     Publication Date:  2010  
Date Detail:
Created Date:  2012-01-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101392236     Medline TA:  Ecancermedicalscience     Country:  England    
Other Details:
Languages:  eng     Pagination:  176     Citation Subset:  -    
Division of Plastic Surgery, University of Missouri, One Hospital Dr, Columbia, MO, USA.
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