Document Detail

A protective antiarrhythmic role of ursodeoxycholic acid in an in vitro rat model of the cholestatic fetal heart.
MedLine Citation:
PMID:  21809354     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: These results illustrate that the appearance of MFBs in the FH may contribute to arrhythmias. The above-described mechanism represents a new therapeutic approach for cardiac arrhythmias at the level of MFB.
Michele Miragoli; Siti H Sheikh Abdul Kadir; Mary N Sheppard; Nicoló Salvarani; Matilda Virta; Sarah Wells; Max J Lab; Viacheslav O Nikolaev; Alexey Moshkov; William M Hague; Stephan Rohr; Catherine Williamson; Julia Gorelik
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article     Date:  2011-08-01
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  54     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-29     Completed Date:  2011-11-29     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1282-92     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Association for the Study of Liver Diseases.
National Heart and Lung Institute, Imperial College London, London, England.
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MeSH Terms
Anti-Arrhythmia Agents / administration & dosage,  pharmacology
Arrhythmias, Cardiac / etiology,  prevention & control*
Cells, Cultured / cytology,  drug effects
Cholestasis, Intrahepatic / complications*,  drug therapy
Disease Models, Animal
Fetal Heart / drug effects*
Heart Ventricles / cytology,  pathology
Muscle Cells / cytology,  physiology
Pregnancy Complications / diagnosis,  drug therapy
Rats, Wistar
Treatment Outcome
Ursodeoxycholic Acid / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 128-13-2/Ursodeoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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