Document Detail


The protection of ischaemic preconditioning can be reinstated in the rabbit heart after the initial protection has waned.
MedLine Citation:
PMID:  8324785     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Preconditioning the heart with 5 min of ischaemia followed by reperfusion renders the myocardium resistant to infarction from subsequent ischaemia. This protection lasts for about 1 h. The aim of this study was to test whether the protection could be reinstated with a second episode of preconditioning after protection from an initial episode had worn off. METHODS: To induce infarction animals experienced 30 min of coronary artery occlusion and then 3 h reperfusion. Ischaemic preconditioning was accomplished with 5 min of coronary branch occlusion. In one group of rabbits the subsequent reperfusion period was prolonged to 2 h to permit protection to wear off before the 30 min coronary occlusion was initiated. In another group a second 5 min coronary occlusion was performed at the end of the 2 h reperfusion. After 10 min of reperfusion the 30 min ischaemic period began. Control animals experienced only the 30 min ischaemia and 3 h reperfusion. Infarct volume was measured with tetrazolium and expressed as a percentage of the ischaemic zone volume. RESULTS: Average infarct size in seven control rabbits [36.0 (SEM 2.0)% of the ischaemic zone] was not significantly different from that in eight rabbits with the prolonged coronary occlusion occurring 2 h after the preconditioning stimulus [28.6 (2.9)% infarction]. In contrast infarcts were significantly smaller in the re-preconditioned group of seven rabbits [8.3 (4.2)%] and comparable to those previously seen with a single preconditioning stimulus followed 10 min later by the 30 min occlusion [6.1 (1.8)%]. CONCLUSIONS: The rabbit heart can be protected with a second preconditioning stimulus after protection from an initial period of preconditioning has subsided.
Authors:
X M Yang; S Arnoult; A Tsuchida; D Cope; J D Thornton; J F Daly; M V Cohen; J M Downey
Related Documents :
9205165 - Intravenous phenylephrine preconditioning of cardiac grafts from non-heart-beating donors.
17522975 - Postconditioning in man.
15644945 - Beyond angiogenesis: the cardioprotective potential of fibroblast growth factor-2.
17281905 - Intravascular parasympathetic cardiac nerve stimulation prevents ventricular arrhythmia...
20466205 - Mesenchymal stem cells provide better results than hematopoietic precursors for the tre...
15944535 - Detecting changes in serial myocardial perfusion spect: a simulation study.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiovascular research     Volume:  27     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-08-12     Completed Date:  1993-08-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  556-8     Citation Subset:  IM    
Affiliation:
University of South Alabama, College of Medicine, Mobile 36688.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Female
Male
Myocardial Infarction / pathology,  prevention & control*
Myocardial Ischemia* / pathology
Myocardial Reperfusion / methods*
Myocardium / pathology
Rabbits
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Ischaemic preconditioning--time course of renewal in the pig.
Next Document:  Hypoxic preconditioning attenuates stunning caused by repeated coronary artery occlusions in dog hea...