| The protection of ischaemic preconditioning can be reinstated in the rabbit heart after the initial protection has waned. | |
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MedLine Citation:
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PMID: 8324785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Preconditioning the heart with 5 min of ischaemia followed by reperfusion renders the myocardium resistant to infarction from subsequent ischaemia. This protection lasts for about 1 h. The aim of this study was to test whether the protection could be reinstated with a second episode of preconditioning after protection from an initial episode had worn off. METHODS: To induce infarction animals experienced 30 min of coronary artery occlusion and then 3 h reperfusion. Ischaemic preconditioning was accomplished with 5 min of coronary branch occlusion. In one group of rabbits the subsequent reperfusion period was prolonged to 2 h to permit protection to wear off before the 30 min coronary occlusion was initiated. In another group a second 5 min coronary occlusion was performed at the end of the 2 h reperfusion. After 10 min of reperfusion the 30 min ischaemic period began. Control animals experienced only the 30 min ischaemia and 3 h reperfusion. Infarct volume was measured with tetrazolium and expressed as a percentage of the ischaemic zone volume. RESULTS: Average infarct size in seven control rabbits [36.0 (SEM 2.0)% of the ischaemic zone] was not significantly different from that in eight rabbits with the prolonged coronary occlusion occurring 2 h after the preconditioning stimulus [28.6 (2.9)% infarction]. In contrast infarcts were significantly smaller in the re-preconditioned group of seven rabbits [8.3 (4.2)%] and comparable to those previously seen with a single preconditioning stimulus followed 10 min later by the 30 min occlusion [6.1 (1.8)%]. CONCLUSIONS: The rabbit heart can be protected with a second preconditioning stimulus after protection from an initial period of preconditioning has subsided. |
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Authors:
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X M Yang; S Arnoult; A Tsuchida; D Cope; J D Thornton; J F Daly; M V Cohen; J M Downey |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cardiovascular research Volume: 27 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 1993 Apr |
Date Detail:
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Created Date: 1993-08-12 Completed Date: 1993-08-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 556-8 Citation Subset: IM |
Affiliation:
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University of South Alabama, College of Medicine, Mobile 36688. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Male Myocardial Infarction / pathology, prevention & control* Myocardial Ischemia* / pathology Myocardial Reperfusion / methods* Myocardium / pathology Rabbits Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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