Document Detail

A prostaglandin theory of neuroleptic malignant syndrome.
MedLine Citation:
PMID:  2891019     Owner:  NLM     Status:  MEDLINE    
A subgroup of patients with schizophrenia or other psychoses may have an increased PGE receptor sensitivity in the brain, which may be due to low levels of PGE. Some of these patients may develop a severe dopaminergic blockade when given neuroleptics which stimulate PGE synthesis. This may lead to the symptoms of neuroleptic malignant syndrome. Calcium channel blockers inhibit the prostaglandin output caused by norepinephrine and these agents may prove useful in the treatment of neuroleptic malignant syndrome.
V K Yeragani; P Chaitin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  24     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1987-12-23     Completed Date:  1987-12-23     Revised Date:  2008-08-15    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  143-9     Citation Subset:  IM    
Lafayette Clinic, Detroit, Michigan 48207.
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MeSH Terms
Catalepsy / physiopathology
Fever / complications
Heat Exhaustion / physiopathology
Malignant Hyperthermia / physiopathology
Neuroleptic Malignant Syndrome / metabolism*,  physiopathology
Prostaglandins E / physiology*
Psychotic Disorders / complications
Receptors, Prostaglandin / physiology
Receptors, Prostaglandin E
Schizophrenia / metabolism
Reg. No./Substance:
0/Prostaglandins E; 0/Receptors, Prostaglandin; 0/Receptors, Prostaglandin E

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