Document Detail

A prostaglandin synthesis inhibitor, diclofenac sodium in the treatment of primary nocturnal enuresis.
MedLine Citation:
PMID:  7484520     Owner:  NLM     Status:  MEDLINE    
Various treatment modalities have been used in Primary Nocturnal Enuresis (PNE) and pharmacotherapy is widely accepted. Prostaglandins increase detrusor pressure, decrease urethral pressure and lead to sodium excretion. They also antagonize hydro-osmotic effect of vasopressin by competing with this hormone. According to these functions of prostaglandins it is suggested that inhibition of prostaglandin synthesis may have value in the management of PNE. We evaluated the efficacy or oral diclofenac sodium treatment in 78 patients. We conclude that diclofenac sodium, an inhibitor of prostaglandin synthesis, is a good alternative agent for nocturnal enuresis particularly as a supplementary treatment combined to Imipramine, with 60% complete response and 13.3% recurrence rate.
E Batislam; B Nuhoğlu; L Peşkircioğlu; L Emir; C Uygur; C Germiyanoğlu; D Erol
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta urologica Belgica     Volume:  63     ISSN:  0001-7183     ISO Abbreviation:  Acta Urol Belg     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1995-12-27     Completed Date:  1995-12-27     Revised Date:  2008-09-24    
Medline Journal Info:
Nlm Unique ID:  0377045     Medline TA:  Acta Urol Belg     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  35-8     Citation Subset:  IM    
Ministry of Health, Ankara Hospital Urology Clinic, Turkey.
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MeSH Terms
Cyclooxygenase Inhibitors / therapeutic use*
Diclofenac / therapeutic use*
Enuresis / drug therapy*
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 15307-86-5/Diclofenac

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