| A prostaglandin D2 system in the human testis. | |
| | |
MedLine Citation:
|
PMID: 17307169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
As shown recently, cyclooxygenase 2 (COX2), the inducible key enzyme for the prostaglandin (PG) biosynthetic pathway, is abundantly present in interstitial cells of testes of men suffering from different forms of impaired spermatogenesis and sub- or infertility, but it is absent in human testes with normal spermatogenesis. Although the spectrum of the downstream products of COX2 action in testis, namely PGs, and their effects are not known, our results show that Prostaglandin D2 (PGD2) likely plays a role. We describe (a) PGD2 synthetases, as well as receptors for PGD2 (DP) in testicular interstitial cells of men suffering from spermatogenic damage and infertility, and report that (b) PGD2 is produced by and can affect Leydig cells of an animal model, which expresses testicular COX2 and DP. |
| | |
Authors:
|
Christoph Schell; Monica B Frungieri; Martin Albrecht; Silvia I Gonzalez-Calvar; Frank M Köhn; Ricardo S Calandra; Artur Mayerhofer |
Related Documents
:
|
9225169 - Luteinizing hormone on leydig cell structure and function. 16728019 - Increased germ cell degeneration and reduced germ cell:sertoli cell ratio in stallions ... 7902679 - Neuroendocrine marker substances in human leydig cells--changes by disturbances of test... 2829579 - Demonstration of hcg binding sites and hcg stimulated steroidogenesis in different popu... 8563189 - In vitro toxicity of 1,2-dibromo-3-chloropropane (dbcp) in different testicular cell ty... 15032329 - Immunodetection of aromatase in mice with a partial deletion in the long arm of the y c... 5787989 - Fungal morphogenesis: cell wall construction in mucor rouxii. 22344269 - Build-up of symmetry breaking using a titanium suboxide in bulk-heterojunction solar ce... 16784529 - Effects of disrupting the polyketide synthase gene wdpks1 in wangiella [exophiala] derm... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-02-20 |
Journal Detail:
|
Title: Fertility and sterility Volume: 88 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2007 Jul |
Date Detail:
|
Created Date: 2007-07-06 Completed Date: 2007-07-31 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
|
Languages: eng Pagination: 233-6 Citation Subset: IM |
Affiliation:
|
Anatomisches Institut am Biederstein, Ludwig-Maximilians-Universität, Munich, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cricetinae Humans Infertility, Male / enzymology, metabolism, pathology Intramolecular Oxidoreductases / analysis, biosynthesis* Leydig Cells / enzymology, metabolism Lipocalins Male Receptors, Immunologic / metabolism Receptors, Prostaglandin / metabolism Retrospective Studies Testis / enzymology*, metabolism, pathology |
| Chemical | |
Reg. No./Substance:
|
0/Lipocalins; 0/Receptors, Immunologic; 0/Receptors, Prostaglandin; 0/prostaglandin D2 receptor; EC 5.3.-/Intramolecular Oxidoreductases; EC 5.3.99.2/prostaglandin R2 D-isomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Expression of CD9 in frozen-thawed mouse oocytes: preliminary experience.
Next Document: A randomized, controlled trial of asoprisnil, a novel selective progesterone receptor modulator, in ...