Document Detail

A prostaglandin D2 system in the human testis.
MedLine Citation:
PMID:  17307169     Owner:  NLM     Status:  MEDLINE    
As shown recently, cyclooxygenase 2 (COX2), the inducible key enzyme for the prostaglandin (PG) biosynthetic pathway, is abundantly present in interstitial cells of testes of men suffering from different forms of impaired spermatogenesis and sub- or infertility, but it is absent in human testes with normal spermatogenesis. Although the spectrum of the downstream products of COX2 action in testis, namely PGs, and their effects are not known, our results show that Prostaglandin D2 (PGD2) likely plays a role. We describe (a) PGD2 synthetases, as well as receptors for PGD2 (DP) in testicular interstitial cells of men suffering from spermatogenic damage and infertility, and report that (b) PGD2 is produced by and can affect Leydig cells of an animal model, which expresses testicular COX2 and DP.
Christoph Schell; Monica B Frungieri; Martin Albrecht; Silvia I Gonzalez-Calvar; Frank M Köhn; Ricardo S Calandra; Artur Mayerhofer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-02-20
Journal Detail:
Title:  Fertility and sterility     Volume:  88     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-06     Completed Date:  2007-07-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  233-6     Citation Subset:  IM    
Anatomisches Institut am Biederstein, Ludwig-Maximilians-Universität, Munich, Germany.
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MeSH Terms
Infertility, Male / enzymology,  metabolism,  pathology
Intramolecular Oxidoreductases / analysis,  biosynthesis*
Leydig Cells / enzymology,  metabolism
Receptors, Immunologic / metabolism
Receptors, Prostaglandin / metabolism
Retrospective Studies
Testis / enzymology*,  metabolism,  pathology
Reg. No./Substance:
0/Lipocalins; 0/Receptors, Immunologic; 0/Receptors, Prostaglandin; 0/prostaglandin D2 receptor; EC 5.3.-/Intramolecular Oxidoreductases; EC R2 D-isomerase

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