Document Detail


The prostacyclin analogue beraprost sodium prevents occlusion of bypass grafts in patients with lower extremity arterial occlusive disease: a 20-year retrospective study.
MedLine Citation:
PMID:  16247707     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although conventional bypass grafting is commonly used to treat ischemia in lower extremities, graft failure often occurs. This study retrospectively analyzed the factors that affect graft patency to help establish more effective treatment of obstructive arterial disease of the lower limbs. Kaplan-Meier analysis was used to estimate graft patency in 90 legs of 80 patients who underwent femoropopliteal bypass (28 vein grafts and 62 expanded polytetrafluoroethylene grafts) between 1984 and 2003. Patients were randomly selected for graft materials in sequential surgical treatment order. After initial analysis, several risk factors and postoperative medication regimens were analyzed to ascertain any association with graft failure. The overall mean patency period for femoropopliteal bypass was 10.5 +/- 0.7 years. Graft occlusion occurred in 20 limbs. Neither the materials composing the grafts nor the position of distal anastmosis had any influence on patency maintenance. Graft occlusion rates were significantly greater in patients with either diabetes (p = 0.0049) or rest pain before surgery (p = 0.0011). Postoperative administration of beraprost sodium significantly increased the patency period (p = 0.0082). Diabetes and rest pain before surgery are important factors for late graft failure after femoropopliteal bypass. Our data also suggest that administration of beraprost sodium increases the graft patency period.
Authors:
Mikiko Murakami; Masazumi Watanabe; Hitoshi Furukawa; Hideki Nakahara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of vascular surgery     Volume:  19     ISSN:  0890-5096     ISO Abbreviation:  Ann Vasc Surg     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-31     Completed Date:  2006-01-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703941     Medline TA:  Ann Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  838-42     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Surgery, Tokyo Metropolitan Hiroo General Hospital, 2-34-10 Ebisu, Shibuya-ku, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Arteriosclerosis Obliterans / surgery*
Blood Vessel Prosthesis Implantation
Diabetic Angiopathies / surgery
Epoprostenol / analogs & derivatives*,  therapeutic use
Female
Femoral Artery / surgery
Graft Occlusion, Vascular / prevention & control*
Humans
Leg / blood supply
Male
Middle Aged
Platelet Aggregation Inhibitors / therapeutic use*
Popliteal Artery / surgery
Postoperative Period
Retrospective Studies
Vascular Patency
Chemical
Reg. No./Substance:
0/Platelet Aggregation Inhibitors; 35121-78-9/Epoprostenol; 88430-50-6/beraprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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