Document Detail

A prospective study to determine the efficacy of antibiotics in acute pancreatitis.
MedLine Citation:
PMID:  788655     Owner:  NLM     Status:  MEDLINE    
This study is a double "blind" prospective evaluation of the efficacy of antibiotics (Ampicillin) in the treatment of acute alcohol-induced and idiopathic pancreatitis. Fifty-eight patients with acute pancreatitis were randomly divided into antibiotic and non-antibiotic treatment groups. The two groups were comparable clinically at the onset of the study and other than for antibiotics received identical therapy. The patients without antibiotics had a clinical course equal or slightly more favorable than the antibiotic treatment group in all parameters examined. These data indicate that prophylactic use of Ampicillin is not indicated in patients with routine acute alcohol-induced or idiopathic pancreatitis. The role of prophylactic antibiotics in patients with pancreatitis related to biliary calculi and those with more severe varieties of acute hemorrhagic or necrotizing pancreatitis remains to be more clearly defined.
W T Finch; J L Sawyers; S Schenker
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Annals of surgery     Volume:  183     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1976-12-03     Completed Date:  1976-12-03     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  667-71     Citation Subset:  AIM; IM    
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MeSH Terms
Acute Disease
Alcoholism / complications
Ampicillin / therapeutic use*
Clinical Trials as Topic
Middle Aged
Pancreatitis / drug therapy*,  etiology,  prevention & control
Prospective Studies
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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