| A prospective study to determine the efficacy of antibiotics in acute pancreatitis. | |
MedLine Citation:
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PMID: 788655 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study is a double "blind" prospective evaluation of the efficacy of antibiotics (Ampicillin) in the treatment of acute alcohol-induced and idiopathic pancreatitis. Fifty-eight patients with acute pancreatitis were randomly divided into antibiotic and non-antibiotic treatment groups. The two groups were comparable clinically at the onset of the study and other than for antibiotics received identical therapy. The patients without antibiotics had a clinical course equal or slightly more favorable than the antibiotic treatment group in all parameters examined. These data indicate that prophylactic use of Ampicillin is not indicated in patients with routine acute alcohol-induced or idiopathic pancreatitis. The role of prophylactic antibiotics in patients with pancreatitis related to biliary calculi and those with more severe varieties of acute hemorrhagic or necrotizing pancreatitis remains to be more clearly defined. |
Authors:
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W T Finch; J L Sawyers; S Schenker |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Annals of surgery Volume: 183 ISSN: 0003-4932 ISO Abbreviation: Ann. Surg. Publication Date: 1976 Jun |
Date Detail:
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Created Date: 1976-12-03 Completed Date: 1976-12-03 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372354 Medline TA: Ann Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 667-71 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Alcoholism / complications Ampicillin / therapeutic use* Clinical Trials as Topic Female Humans Male Middle Aged Pancreatitis / drug therapy*, etiology, prevention & control Prospective Studies |
| Chemical | |
Reg. No./Substance:
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69-53-4/Ampicillin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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