Document Detail


A prospective study of thyroid function, bone loss, and fractures in older men: The MrOS study.
MedLine Citation:
PMID:  23018684     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Excess thyroid hormone is associated with increased bone loss and fracture risk in older women, but few data exist for men. We sought to determine if thyroid function is independently associated with bone loss and fracture risk in older men. Data were analyzed from the Osteoporotic Fractures in Men (MrOS) study, a cohort of community-dwelling U.S. men aged 65 years and older. Using a case-cohort design, fasting baseline serum archived at -80°C was assayed for thyroid-stimulating hormone (thyrotropin) (TSH) and free thyroxine (FT4) in 397 men with confirmed nonspine fracture, including 157 hip fractures, and 1420 randomly selected men without fracture. TSH and FT4 were analyzed as continuous variables and as thyroid function categories (subclinical hyperthyroid, euthyroid, and subclinical hypothyroid). Hip dual-energy X-ray absorptiometry (DXA) (Hologic QDR4500) was measured at baseline and after a mean follow-up of 4.6 years. Incident nonspine fractures were centrally adjudicated. Bone loss was evaluated with multivariate regression methods and fractures risk was evaluated using hazard models that accounted for the case-cohort sampling, adjusted for age, clinic-site, body mass index (BMI), race, physical activity, corticosteroid use, smoking, alcohol intake, and thyroid medication use. In fully adjusted analyses, TSH was not associated with risk of nonspine fracture (relative hazard [RH] 0.92 per SD decrease in TSH; 95% confidence interval [CI], 0.74-1.14), but was significantly associated with risk of hip fracture (RH 1.31; 95% CI, 1.01-1.71), which persisted among normal range TSH values (RH 1.21; 95% CI, 1.00-1.47). There was no association between TSH or FT4 and bone loss, and fracture risk did not differ significantly by thyroid function category. We conclude that although neither TSH nor FT4 are associated with bone loss, lower serum TSH may be associated with an increased risk of hip fractures in older men.
Authors:
Avantika C Waring; Stephanie Harrison; Howard A Fink; Mary H Samuels; Peggy M Cawthon; Joseph M Zmuda; Eric S Orwoll; Douglas C Bauer;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research     Volume:  28     ISSN:  1523-4681     ISO Abbreviation:  J. Bone Miner. Res.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-18     Completed Date:  2013-08-29     Revised Date:  2014-08-06    
Medline Journal Info:
Nlm Unique ID:  8610640     Medline TA:  J Bone Miner Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  472-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Society for Bone and Mineral Research.
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MeSH Terms
Descriptor/Qualifier:
Absorptiometry, Photon
Aged
Fractures, Bone / physiopathology*
Humans
Male
Osteoporosis / physiopathology*
Prospective Studies
Thyroid Function Tests*
Thyroid Hormones / blood
Grant Support
ID/Acronym/Agency:
K24 AR051895/AR/NIAMS NIH HHS; U01 AG18197/AG/NIA NIH HHS; U01 AR45580/AR/NIAMS NIH HHS; U01 AR45583/AR/NIAMS NIH HHS; U01 AR45614/AR/NIAMS NIH HHS; U01 AR45632/AR/NIAMS NIH HHS; U01 AR45647/AR/NIAMS NIH HHS; U01 AR45654/AR/NIAMS NIH HHS; U01-AG027810/AG/NIA NIH HHS; UL1 RR024140/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Thyroid Hormones
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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