Document Detail

A prospective study on radiofrequency ablation locally advanced pancreatic cancer.
MedLine Citation:
PMID:  20525559     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Radiofrequency ablation (RFA) has been suggested as a new treatment option for patients with locally advanced cancer. This study aimed to prospectively evaluate the efficacy and safety of intraoperative RFA in patients with unresectable, locally advanced, non-metastatic carcinoma of the pancreatic head. METHODS: RFA was the first step of the surgical procedure and was carried out on the mobilized pancreatic head followed by biliary by-pass and gastrojejunal-anastomosis. Intra- and post-operative morbidity and mortality, performance status, pain control, quality of life, and survival at 24 months were evaluated. RESULTS: Seven patients (3 men and 4 women; median age 66 years, range 47-80 years) were studied and 4 were eligible for treatment. The RFA procedure was carried out in 3 of the 4 patients; in one patient it was not carried out because of the upstaging of the neoplasm. In all 3 patients RFA achieved complete necrosis of the lesion. A biliary fistula developed 7 days after the procedure in one patient; all 3 patients developed ascites 8.6 days (range 7-9 days) on average after RFA. All patients died respectively, at 3, 4, and 5 months after the treatment. CONCLUSIONS: In our experience, RFA is a feasible procedure, but it presents a very high rate of postoperative complications. Moreover, pain control, life quality and survival rate are poor. The few data suggest no impact on survival.
Riccardo Casadei; Claudio Ricci; Raffaele Pezzilli; Carla Serra; Lucia Calculli; Antonio Maria Morselli-Labate; Donatella Santini; Francesco Minni
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepatobiliary & pancreatic diseases international : HBPD INT     Volume:  9     ISSN:  1499-3872     ISO Abbreviation:  HBPD INT     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-07     Completed Date:  2010-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101151457     Medline TA:  Hepatobiliary Pancreat Dis Int     Country:  China    
Other Details:
Languages:  eng     Pagination:  306-11     Citation Subset:  IM    
Department of Surgery, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
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MeSH Terms
Adenocarcinoma / mortality,  pathology,  surgery*
Aged, 80 and over
Ascites / etiology
Biliary Fistula / etiology
Catheter Ablation* / adverse effects,  mortality
Gastric Bypass
Middle Aged
Neoplasm Invasiveness
Pain, Postoperative / etiology
Pancreatic Neoplasms / mortality,  pathology,  surgery*
Prospective Studies
Quality of Life
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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