Document Detail


A prospective study of posttransfusion hepatitis in Taiwan.
MedLine Citation:
PMID:  1655869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a follow-up study of 6 months or more of two hundred and ninety-six patients who had received blood transfusion, 37 (12.5%) developed acute posttransfusion hepatitis. Patients with posttransfusion hepatitis had significantly higher donor numbers and transfusion amounts than patients without hepatitis. Frequency was not related to the age, sex or hepatitis B carriage of recipients. There were no cases of fulminant hepatitis. Of 37 patients with hepatitis, 36 were diagnosed as non-A, non-B hepatitis and one as hepatitis B. Twenty-two (59.5%) of the 36 patients with non-A, non-B hepatitis seroconverted to hepatitis C antibody. Two of these were positive for hepatitis C antibody before transfusion and 12 were negative for hepatitis C antibody. Thirty-three of the 36 patients were followed-up for more than 6 months after the onset of hepatitis. While 13 of the 33 patients recovered, the remaining 20 (60.6%) patients still had persistent liver test abnormalities 6 months after the onset of hepatitis. Seventeen (85%) of the 20 patients who developed chronic hepatitis were hepatitis C antibody positive. In contrast, only four (30%) of the 13 patients who recovered after acute hepatitis were positive for the hepatitis C antibody. Chronicity rate was not related to the patient's sex, age, transfusion amount or donor number. Our results suggest a high frequency of posttransfusion hepatitis C in Taiwan and that the infection has a high risk of chronicity.
Authors:
T H Wang; J T Wang; J T Lin; J C Sheu; J L Sung; D S Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hepatology     Volume:  13     ISSN:  0168-8278     ISO Abbreviation:  J. Hepatol.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-11-14     Completed Date:  1991-11-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  38-43     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Blood Transfusion / adverse effects*
Chronic Disease
Enzyme-Linked Immunosorbent Assay
Female
Hepacivirus / immunology
Hepatitis Antibodies / immunology
Hepatitis B / diagnosis,  epidemiology,  immunology
Hepatitis C / epidemiology*,  etiology,  immunology
Humans
Male
Middle Aged
Prospective Studies
Risk Factors
Taiwan / epidemiology
Chemical
Reg. No./Substance:
0/Hepatitis Antibodies

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