Document Detail

A prospective study of oesophageal 24-h ambulatory pH monitoring in patients with functional dyspepsia.
MedLine Citation:
PMID:  15733519     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The diagnostic utility of 24-h oesophageal ambulatory pH monitoring in patients with functional dyspepsia has not been well established. AIMS: We performed a prospective study of oesophageal pH monitoring in patients with functional dyspepsia in order to assess whether a positive pH test might predict response to proton pump inhibitor therapy in a subset of functional dyspepsia patients. PATIENTS: Forty Helicobacter pylori-negative functional dyspepsia patients (35 males and 5 females, mean age (+/-S.E.M.) of 54+/-2.4 years) with predominantly unspecified dyspepsia subtype and normal distal oesophageal biopsies. METHODS: All subjects were randomised in a double-blind fashion to either omeprazole 20 mg/day or placebo daily for four weeks after 24-h pH monitoring. RESULTS: Twenty-four-hour pH monitoring was abnormal in 9 of the 21 patients (43%) in the omeprazole group and 5/19 (26%) of the placebo group (p=NS). Patients who reported symptomatic improvement on the Gastrointestinal Symptom Rating Scale were no more likely to have abnormal scores on pH monitoring than patients who did not have symptomatic response. CONCLUSIONS: Although approximately one-third of functional dyspepsia patients will have abnormal profiles on 24-h ambulatory oesophageal pH monitoring, an abnormal score does not appear to predict response to proton pump inhibitor therapy in patients with unspecified functional dyspepsia.
L B Gerson; G Triadafilopoulos
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver     Volume:  37     ISSN:  1590-8658     ISO Abbreviation:  Dig Liver Dis     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-28     Completed Date:  2005-06-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100958385     Medline TA:  Dig Liver Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  87-91     Citation Subset:  IM    
Division of Gastroenterology and Hepatology, A 149, Stanford University School of Medicine, Stanford University, Stanford, CA 94305-5202, USA.
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MeSH Terms
Anti-Ulcer Agents / therapeutic use
Double-Blind Method
Dyspepsia / drug therapy,  physiopathology*
Esophagus / physiopathology*
Hydrogen-Ion Concentration
Middle Aged
Monitoring, Ambulatory
Monitoring, Physiologic
Omeprazole / therapeutic use
Prospective Studies
Treatment Outcome
Reg. No./Substance:
0/Anti-Ulcer Agents; 73590-58-6/Omeprazole

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