Document Detail

A prospective study of the natural history of hematuria associated with benign prostatic hyperplasia and the effect of finasteride.
MedLine Citation:
PMID:  10647664     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We prospectively studied the effect of finasteride on chronic hematuria associated with benign prostatic hyperplasia. MATERIALS AND METHODS: We prospectively evaluated 57 patients with chronic intermittent hematuria who were randomized to a finasteride treated or a control arm. RESULTS: In the untreated control group hematuria recurred in 17 patients (63%) within a year but in only 4 (14%) in the finasteride group, which was a statistically significant difference (p <0.05). Surgery was required for bleeding in 7 controls (26%), while no patient on finasteride required surgery. CONCLUSIONS: Hematuria secondary to prostatic bleeding may be significant if not treated. Finasteride appears to be effective for suppressing hematuria caused by benign prostatic hyperplasia and should be considered as treatment.
S J Foley; L Z Soloman; A W Wedderburn; K M Kashif; D Summerton; V Basketter; S A Holmes
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of urology     Volume:  163     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-02-10     Completed Date:  2000-02-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  496-8     Citation Subset:  AIM; IM    
Department of Urology, St. Mary's Hospital, Portsmouth, United Kingdom.
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MeSH Terms
Aged, 80 and over
Enzyme Inhibitors / therapeutic use*
Finasteride / therapeutic use*
Follow-Up Studies
Hematuria / drug therapy*,  etiology*
Middle Aged
Prospective Studies
Prostatic Hyperplasia / complications*
Reg. No./Substance:
0/Enzyme Inhibitors; 98319-26-7/Finasteride
Comment In:
J Urol. 2000 Nov;164(5):1670-1   [PMID:  11203073 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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