Document Detail


A prospective study of the natural history of hematuria associated with benign prostatic hyperplasia and the effect of finasteride.
MedLine Citation:
PMID:  10647664     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: We prospectively studied the effect of finasteride on chronic hematuria associated with benign prostatic hyperplasia. MATERIALS AND METHODS: We prospectively evaluated 57 patients with chronic intermittent hematuria who were randomized to a finasteride treated or a control arm. RESULTS: In the untreated control group hematuria recurred in 17 patients (63%) within a year but in only 4 (14%) in the finasteride group, which was a statistically significant difference (p <0.05). Surgery was required for bleeding in 7 controls (26%), while no patient on finasteride required surgery. CONCLUSIONS: Hematuria secondary to prostatic bleeding may be significant if not treated. Finasteride appears to be effective for suppressing hematuria caused by benign prostatic hyperplasia and should be considered as treatment.
Authors:
S J Foley; L Z Soloman; A W Wedderburn; K M Kashif; D Summerton; V Basketter; S A Holmes
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of urology     Volume:  163     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-02-10     Completed Date:  2000-02-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  496-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Urology, St. Mary's Hospital, Portsmouth, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Enzyme Inhibitors / therapeutic use*
Finasteride / therapeutic use*
Follow-Up Studies
Hematuria / drug therapy*,  etiology*
Humans
Male
Middle Aged
Prospective Studies
Prostatic Hyperplasia / complications*
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 98319-26-7/Finasteride
Comments/Corrections
Comment In:
J Urol. 2000 Nov;164(5):1670-1   [PMID:  11203073 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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