| A prospective study of left ventricle function after treatment with rapid-infusion rituximab in patients with non-Hodgkin lymphoma. | |
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MedLine Citation:
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PMID: 19757315 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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We designed a prospective study to measure the left ventricular ejection fraction of 42 patients with non-Hodgkin lymphoma treated with Rituximab-based chemotherapy in a 1-h infusion. Our patients were not selected on the basis of their cardiac status. Cardiac history and other forms of co-morbidity were to be identified on entry. Before treatment, basal left ventricular ejection function (LVEF) was measured and every 6 months after treatment. Most patients were treated with CHOP-Rituximab combinations (79%). A drop in the post-treatment ejection fraction of over 10% from the pre-treatment base figure was found in 13 patients (31% of the total of the series, 39% of those receiving adriamycin-based chemotherapy). None of the patients without adriamycin had a decrease in LVEF. Three patients with drop >10% recovered normally, but when LVEF decreased by over 15%, which occurred in six patients (14.2%), none of them recovered normal level. Patients with normal systolic function had LVEF with a mean of 64.09 (+/-3.86) and patients with decreased systolic function had LVEF with a mean of 59.38 (+/-5.43). Though the data in this study suggest that rapid-infusion Rituximab does not cause relevant cardiac toxicity, there was a high percentage of reductions in LVEF of over 10%. |
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Authors:
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Mariano Provencio; Antonio Sanchez; Constanza Maximiano; Blanca Cantos; Miriam Méndez; Félix Bonilla |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Leukemia & lymphoma Volume: 50 ISSN: 1029-2403 ISO Abbreviation: Leuk. Lymphoma Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-11-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007422 Medline TA: Leuk Lymphoma Country: England |
Other Details:
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Languages: eng Pagination: 1642-6 Citation Subset: IM |
Affiliation:
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Department of Medical Oncology, Puerta de Hierro University Hospital, Madrid, Spain. mprovenciop@gmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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