| A prospective study of PET/CT in initial staging of small-cell lung cancer: comparison with CT, bone scintigraphy and bone marrow analysis. | |
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MedLine Citation:
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PMID: 17060487 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Small-cell lung cancer (SCLC) accounts for 15%-20% of all lung cancer cases. Accurate and fast staging is mandatory when choosing treatment, but current staging procedures are time consuming and lack sensitivity. PATIENTS AND METHODS: A prospective study was designed to examine the role of combined positron emission tomography/computed tomography (PET/CT) compared with standard staging (CT, bone scintigraphy and immunocytochemical assessment of bone marrow biopsy) of patients with SCLC. Thirty-four consecutive patients were included. Twenty-nine patients received initial PET/CT. RESULTS: PET/CT caused change of stage in 5/29 (17%). Excluding patients with unconfirmed findings or pleural effusion, the sensitivity for accurate staging of patients with extensive disease was the following: for standard staging 79%, PET 93% and PET/CT 93%. Specificity was 100%, 83% and 100%, respectively. CONCLUSION: The results from this first study on PET/CT in SCLC indicates that PET/CT can simplify and perhaps even improve the accuracy of the current staging procedure in SCLC. A larger clinical trial, preferably with consequent histological confirmation in case of discordance, however, is warranted. |
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Authors:
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B M Fischer; J Mortensen; S W Langer; A Loft; A K Berthelsen; B I Petersen; G Daugaard; U Lassen; H H Hansen |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2006-10-23 |
Journal Detail:
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Title: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO Volume: 18 ISSN: 0923-7534 ISO Abbreviation: Ann. Oncol. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-07 Completed Date: 2007-05-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007735 Medline TA: Ann Oncol Country: England |
Other Details:
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Languages: eng Pagination: 338-45 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine and PET, Copenhagen University Hospital, Copenhagen, Denmark. malene.fischer@rh.dk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Bone Marrow / pathology* Bone Neoplasms / radionuclide imaging*, secondary Carcinoma, Small Cell / pathology, radiography*, radionuclide imaging* Female Fluorodeoxyglucose F18 / diagnostic use Humans Lung Neoplasms / pathology, radiography*, radionuclide imaging* Male Middle Aged Neoplasm Staging Positron-Emission Tomography Prospective Studies Radiopharmaceuticals / diagnostic use Sensitivity and Specificity Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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