Document Detail


A prospective study of findings and management in 214 patients with oral lichen planus.
MedLine Citation:
PMID:  1812447     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The findings in this prospective study of 214 patients with oral lichen planus were similar to those found in our 1985 evaluation of 570 patients with oral lichen planus. These two groups of patients with oral lichen planus patients constitute the largest series from one clinic. Oral lichen planus was found mainly in women and most commonly on the buccal mucosa. Spontaneous remissions were infrequent (6.5%), as were malignant transformations (2.3%) in a mean follow-up of 7.5 years. The erosive form of oral lichen planus was most common and was almost always associated with pain. Reproducibly successful management of this T-lymphocyte disease was obtained by selective use of systemic and/or topical corticosteroids. Oral lichen planus was not associated with any evident systemic disease, drug, smoking, or genetic predisposition. Although statistically Candida albicans does not appear to occur disproportionately in large samples of patients with oral lichen planus, in some of the Candida-positive patients, antifungal medications appeared to be useful.
Authors:
S Silverman; M Gorsky; F Lozada-Nur; K Giannotti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oral surgery, oral medicine, and oral pathology     Volume:  72     ISSN:  0030-4220     ISO Abbreviation:  Oral Surg. Oral Med. Oral Pathol.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-06-08     Completed Date:  1992-06-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376406     Medline TA:  Oral Surg Oral Med Oral Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  665-70     Citation Subset:  D; IM    
Affiliation:
School of Dentistry, University of California, San Francisco 94143.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Aged
Aged, 80 and over
Azathioprine / therapeutic use
Carboxymethylcellulose / therapeutic use
Female
Fluocinonide / therapeutic use
Follow-Up Studies
Humans
Lichen Planus / drug therapy*,  pathology*
Male
Middle Aged
Mouth Diseases / drug therapy,  pathology*
Prednisone / administration & dosage
Prospective Studies
Treatment Outcome
Chemical
Reg. No./Substance:
356-12-7/Fluocinonide; 446-86-6/Azathioprine; 53-03-2/Prednisone; 81209-86-1/Orabase; 9004-32-4/Carboxymethylcellulose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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