| A prospective study of the emergence of early behavioral signs of autism. | |
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MedLine Citation:
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PMID: 20410715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine prospectively the emergence of behavioral signs of autism in the first years of life in infants at low and high risk for autism. METHOD: A prospective longitudinal design was used to compare 25 infants later diagnosed with an autism spectrum disorder (ASD) with 25 gender-matched low-risk children later determined to have typical development. Participants were evaluated at 6, 12, 18, 24, and 36 months of age. Frequencies of gaze to faces, social smiles, and directed vocalizations were coded from video and rated by examiners. RESULTS: The frequency of gaze to faces, shared smiles, and vocalizations to others were highly comparable between groups at 6 months of age, but significantly declining trajectories over time were apparent in the group later diagnosed with ASD. Group differences were significant by 12 months of age on most variables. Although repeated evaluation documented loss of skills in most infants with ASD, most parents did not report a regression in their child's development. CONCLUSIONS: These results suggest that behavioral signs of autism are not present at birth, as once suggested by Kanner, but emerge over time through a process of diminishment of key social communication behaviors. More children may present with a regressive course than previously thought, but parent report methods do not capture this phenomenon well. Implications for onset classification systems and clinical screening are also discussed. |
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Authors:
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Sally Ozonoff; Ana-Maria Iosif; Fam Baguio; Ian C Cook; Monique Moore Hill; Ted Hutman; Sally J Rogers; Agata Rozga; Sarabjit Sangha; Marian Sigman; Mary Beth Steinfeld; Gregory S Young |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of the American Academy of Child and Adolescent Psychiatry Volume: 49 ISSN: 1527-5418 ISO Abbreviation: J Am Acad Child Adolesc Psychiatry Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-04-22 Completed Date: 2010-08-30 Revised Date: 2012-10-11 |
Medline Journal Info:
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Nlm Unique ID: 8704565 Medline TA: J Am Acad Child Adolesc Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 256-66.e1-2 Citation Subset: IM |
Affiliation:
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MIND Institute, University of California-Davis, Sacramento, California 95817, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age of Onset Autistic Disorder / diagnosis*, psychology Child Child Development Disorders, Pervasive / diagnosis*, psychology Child, Preschool Communication Early Diagnosis Female Humans Infant Language Development Disorders / diagnosis, psychology Longitudinal Studies Male Motor Skills Personality Assessment Prospective Studies Regression (Psychology) Retrospective Studies Social Behavior* |
| Grant Support | |
ID/Acronym/Agency:
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R01 MH068398/MH/NIMH NIH HHS; R01 MH068398/MH/NIMH NIH HHS; R01 MH068398-05/MH/NIMH NIH HHS; R01 MH068398-08/MH/NIMH NIH HHS; R01 MH068398-09/MH/NIMH NIH HHS; U54 MH068172/MH/NIMH NIH HHS |
| Comments/Corrections | |
Comment In:
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J Am Acad Child Adolesc Psychiatry. 2010 Mar;49(3):208-9
[PMID:
20410709
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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