Document Detail

A prospective study of the clinical significance of the treatment of gallstones with chenodeoxycholic acid.
MedLine Citation:
PMID:  6463820     Owner:  NLM     Status:  MEDLINE    
Three hundred and forty-two consecutive patients admitted for cholecystectomy were taken into consideration for medical treatment with CDC. Twenty-two patients were eligible for such treatment. The remainder were excluded for the following reasons: 1, emergency operation in 20; 2, nonfunctioning gallbladder in 136; 3, large gallstones in 100; 4, radiopaque calculus in 30, and 5, hepatic disease in seven. Other reasons for surgical treatment were fertile women without adequate contraception, severe biliary tract symptoms, indication for exploratory laparotomy and insufficiency in handling the medication. Twelve patients were treated with CDC. One patient had complete dissolution of the gallstone. It is concluded that the introduction of medical treatment with CDC did not reduce the number of cholecystectomies at a surgical clinic.
G Johansson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgery, gynecology & obstetrics     Volume:  159     ISSN:  0039-6087     ISO Abbreviation:  Surg Gynecol Obstet     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-09-11     Completed Date:  1984-09-11     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0101370     Medline TA:  Surg Gynecol Obstet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  127-9     Citation Subset:  AIM; IM    
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MeSH Terms
Chenodeoxycholic Acid / adverse effects,  therapeutic use*
Cholelithiasis / drug therapy*,  surgery
Diarrhea / chemically induced
Drug Evaluation
Middle Aged
Time Factors
Reg. No./Substance:
474-25-9/Chenodeoxycholic Acid

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