Document Detail

A prospective study of acute central retinal artery obstruction. The incidence of secondary ocular neovascularization.
MedLine Citation:
PMID:  1706177     Owner:  NLM     Status:  MEDLINE    
We conducted a prospective study to determine the incidence of ocular neo-vascularization following acute central retinal artery obstruction. Only patients initially evaluated within 7 days of visual loss were eligible. Any patient with pre-existing ocular neovascularization or clinical evidence of the ocular ischemic syndrome noted at the initial evaluation was excluded. During the 18-month study, 33 consecutive patients were enrolled. Six patients subsequently developed neovascularization of the iris, an incidence of 18.2%. In these six patients, neovascularization of the iris appeared as early as 12 days to as late as 15 weeks following the artery obstructions. Five of the six patients (15.2% of the total) later developed neovascular glaucoma. Another patient in this series developed neovascularization of the optic disc without neovascularization of the iris, an incidence of 3.0%. Only two of the seven patients with ocular neovascularization had ipsilateral hemodynamically significant carotid artery disease as determined by noninvasive carotid artery testing. This study confirms results of previous retrospective studies that the incidence of ocular neovascularization after central retinal artery obstruction is higher than commonly thought. It also shows that, in the majority of cases, carotid artery disease is not responsible for the neovascularization seen after central retinal artery obstruction.
J S Duker; A Sivalingam; G C Brown; R Reber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  109     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-04-15     Completed Date:  1991-04-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  339-42     Citation Subset:  AIM; IM    
Retina Vascular Unit, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pa.
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MeSH Terms
Acute Disease
Aged, 80 and over
Carotid Artery Diseases / complications
Glaucoma, Neovascular / etiology
Iris / blood supply*
Middle Aged
Neovascularization, Pathologic*
Optic Disk / blood supply*
Prospective Studies
Retinal Artery Occlusion / complications*
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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