Document Detail

A prospective study on C-reactive protein as a prognostic factor for survival time of terminally ill cancer patients.
MedLine Citation:
PMID:  17235502     Owner:  NLM     Status:  MEDLINE    
GOALS OF WORK: C-reactive protein (CRP) has been investigated as a predictor of life expectancy in terminal cancer in one previous study. However, the other variables such as patient's symptom or physical examination findings were not considered. The aim of this study is to prove serum CRP level as a predictor of survival time, considering patient's symptoms, physical examination findings, and various serological variables in terminally ill cancer patients with a prospective cohort design. PATIENTS AND METHODS: Forty-four terminally ill cancer patients were divided into two groups by serum CRP levels and followed up until death. We adjusted the influence of some clinical and laboratory variables on survival by use of Cox's proportional hazard model. Using the stepwise variable selection method, we found the final model. For 19 patients, CRP levels at 2 weeks and a week before death were compared by Wilcoxon signed ranks test. MAIN RESULTS: All 44 study subjects died during the study period, and the median survival time was 17 days. Survival time of the elevated CRP group (> or =2.2 mg/dl) was found to be significantly shorter than the lower CRP group in univariate analysis (hazard rate = 3.221, P = 0.001). In multivariate analysis, elevated CRP level (> or =2.2 mg/dl) was selected as one of the unfavorable indicators regarding survival. Dyspnea and hyperbilirubinemia were also found significant predictors of shorter life expectancy in the final model. Serum CRP levels were significantly increased between the first and the second week before death. CONCLUSIONS: Our results showed that serum CRP level can be a useful indicator predictive of survival time of terminally ill cancer patients.
Sang-Yeon Suh; Hong-Yup Ahn
Publication Detail:
Type:  Journal Article     Date:  2007-01-18
Journal Detail:
Title:  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer     Volume:  15     ISSN:  0941-4355     ISO Abbreviation:  Support Care Cancer     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-07-04     Completed Date:  2007-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9302957     Medline TA:  Support Care Cancer     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  613-20     Citation Subset:  IM    
Department of Family Medicine, Dongguk University International Hospital, 814 Siksa-Dong, Ilsan-dong-Gu, Koyang-Si, Gyeonggi-Do, Republic of Korea.
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MeSH Terms
Aged, 80 and over
C-Reactive Protein / analysis*
Middle Aged
Multivariate Analysis
Neoplasm Staging
Neoplasms / blood*,  mortality*,  pathology
Proportional Hazards Models
Prospective Studies
Survival Analysis
Terminally Ill*
Reg. No./Substance:
9007-41-4/C-Reactive Protein

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