| A prospective study of 18 infants of chronic HBsAg mothers. | |
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MedLine Citation:
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PMID: 92218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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28 of 1002 pregnant Sicilian women (2.8%) were asymptomatic HBsAg chronic carriers. 18 children of these women were followed and at least 15 of them showed evidence of transplacental infection with HBsAg, resulting either from the presence of the antigen in cord blood, or from the development of the corresponding antibody in the serum within the first 2 months of life. Despite this, only 2 or 3 of the infants developed chronic antigenaemia from age 2--4 months. Only the infants whose mothers were HBeAb-negative, and who themselves remained HBsAb-negative during the first months of life, became HBsAg carriers. On the basis of these results, a strategy is suggested for selecting infants from areas with a high prevalence of HBsAg carriers so that they can be given passive immunisation with hyperimmune globulin. |
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Authors:
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F Mollica; S Musumeli; S Rugolo; T Mattina |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of disease in childhood Volume: 54 ISSN: 1468-2044 ISO Abbreviation: Arch. Dis. Child. Publication Date: 1979 Oct |
Date Detail:
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Created Date: 1980-01-19 Completed Date: 1980-01-19 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372434 Medline TA: Arch Dis Child Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 750-4 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carrier State
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immunology,
prevention & control Female Fetal Blood / analysis Hepatitis B / immunology*, transmission Hepatitis B Antibodies / analysis Hepatitis B Surface Antigens / analysis* Humans Infant Infant, Newborn Infant, Newborn, Diseases / immunology* Maternal-Fetal Exchange* Pregnancy Prospective Studies gamma-Globulins / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Hepatitis B Antibodies; 0/Hepatitis B Surface Antigens; 0/gamma-Globulins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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