| A prospective randomized trial comparing low-dose ethinyl estradiol and drospirenone 24/4 combined oral contraceptive vs. ethinyl estradiol and drospirenone 21/7 combined oral contraceptive in the treatment of hirsutism. | |
| | |
MedLine Citation:
|
PMID: 22018126 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: A prospective randomized trial was conducted to compare the clinical efficacy of two oral contraceptives containing drospirenone in the treatment of hirsutism in women. STUDY DESIGN: Fifty women with moderate to severe hirsutism were recruited. Three women were lost to follow-up. Twenty-four patients received oral 0.03 mg ethinyl estradiol and 3 mg drospirenone 21/7 regimen (Group 1) for 6 months. Another group of 23 patients received oral 0.02 mg ethinyl estradiol and 3 mg drospirenone 24/4 regimen (Group 2) for 6 months. Hirsutism was assessed after 6 months using the Ferriman-Gallwey (F-G) scoring system. Hormonal levels after 6 months of both therapies were compared with baseline values and each other. RESULTS: An improvement in the F-G scores for hirsutism (mean±SD) was observed in Group 1 (17.3±5.2 to 8.7±2.5, p<.001) and in Group 2 (17.5±4.8 to 7.9±2.8, p<.001). Pre- and post-treatment hirsutism scores were comparable between the groups (p>.05). Total and free testosterone levels decreased significantly after the therapy in both groups. The sex hormone-binding globulin levels increased significantly in both groups during the 6-month period. CONCLUSION: The treatment of hirsutism with both combined oral contraceptives (COCs) containing drospirenone offered comparable effects and was well tolerated. |
| | |
Authors:
|
Gokalp Oner; Iptisam Ipek Muderris |
Related Documents
:
|
21675956 - Safety of vascular endothelial and hepatocyte growth factor gene therapy in patients wi... 22111776 - Advances in oral anticoagulants: focus on dabigatran etexilate. 21858956 - Redefining retention: recovery from the patient's perspective. 12818266 - Effects of 6-12 months of esomeprazole treatment on the gastric mucosa. 2295766 - Incidence and prognosis of acute renal failure in older patients. 16401536 - Surgical treatment of paraannular aortic abscess. |
Publication Detail:
|
Type: Journal Article Date: 2011-04-15 |
Journal Detail:
|
Title: Contraception Volume: 84 ISSN: 1879-0518 ISO Abbreviation: Contraception Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-10-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0234361 Medline TA: Contraception Country: United States |
Other Details:
|
Languages: eng Pagination: 508-11 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Outcomes of medical abortion through 63 days in women with twin gestations.
Next Document: Hormonal contraception and area of cervical ectopy: a longitudinal assessment.