Document Detail

A prospective randomized trial comparing lidocaine and lubricating gel on pain level in patients undergoing transrectal ultrasound prostate biopsy.
MedLine Citation:
PMID:  12243656     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare patient reported pain during TRUS guided biopsies using intrarectal lidocaine gel versus lubricating gel. MATERIALS AND METHODS: From May 2000 to May 2001, 360 men undergoing transrectal prostate biopsy were enrolled in this study. Patients were randomized into two groups. In group 1, 180 patients received 10 cc of 2% intrarectal lidocaine gel (Xylocaine 2% jelly, Astra Pharma Inc.) 5 to 10 minutes before the procedure and in group 2, 180 patients received 10 cc of lubricating gel. No other sedation or analgesia was given. Pain level immediately after the last biopsy was assessed using a 10-point linear visual analog pain scale. RESULTS: The median pain score during transrectal prostate biopsy was 2 (range 0 to 8) and 3 (range 1 to 10) in groups 1 and 2, respectively (p = 0.0001). Only minor complications occurred and complication rates were not significantly different between the groups. CONCLUSION: Rectal administration of lidocaine gel is safe, simple and effective for reducing the pain level associated with transrectal prostate biopsy.
Fred Saad; Robert Sabbagh; Michael McCormack; François Péloquin
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Canadian journal of urology     Volume:  9     ISSN:  1195-9479     ISO Abbreviation:  Can J Urol     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-09-23     Completed Date:  2002-12-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9515842     Medline TA:  Can J Urol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1592-4     Citation Subset:  IM    
Division of Urology, Centre Hospitalier de l'Université de Montréal, Université de Montréal, Montréal, Québec, Canada.
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MeSH Terms
Anesthetics, Local / therapeutic use*
Biopsy / methods
Gels / therapeutic use
Lidocaine / therapeutic use*
Pain Measurement
Prospective Studies
Prostatic Neoplasms / diagnosis*,  ultrasonography
Ultrasound, High-Intensity Focused, Transrectal*
Reg. No./Substance:
0/Anesthetics, Local; 0/Gels; 137-58-6/Lidocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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