| A prospective randomized trial comparing the efficacy of Letrozole and Clomiphene citrate in induction of ovulation in polycystic ovarian syndrome. | |
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MedLine Citation:
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PMID: 22870010 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To compare the efficacy of letrozole and clomiphene citrate (CC) in patients of anovulatory polycystic ovarian syndrome (PCOS) with infertility. MATERIALS AND METHODS: This prospective randomized clinical trial included 204 patients of PCOS. 98 patients (294 cycles) received 2.5-5 mg of letrozole; 106 patients (318 cycles) received 50-100 mg of CC (both orally from Days 3-7 of menstrual cycle). The treatment continued for three cycles in both the groups. MAIN OUTCOME MEASURES: ovulation rate, endometrial thickness, and pregnancy rate. Statistical analysis was done using SPSS 13 software. P value less than 0.05 was considered significant. RESULTS: The mean number of dominant follicles in letrozole groups and CC groups was 1.86±0.26 and 1.92±0.17, respectively (P=0.126). Number of ovulatory cycle in letrozole group was 196 (66.6%) versus 216 (67.9%) in CC group (P=0.712). The mean mid-cycle endometrial thickness was 9.1±0.3 mm in letrozole group and 6.3±1.1 in CC group, which was statistically significant (P=0.014). The mean Estradiol [E2] level in clomiphene citrate group was significantly higher in CC group (364.2±71.4 pg/mL) than letrozole group (248.2± 42.2 pg/mL). 43 patients from the letrozole group (43.8%) and 28 patients from the CC group (26.4%) became pregnant. CONCLUSION: Letrozole and CC have comparable ovulation rate. The effect of letrozole showed a better endometrial response and pregnancy rate compared with CC. |
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Authors:
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Kallol Kumar Roy; Jinee Baruah; Shilpa Singla; Jai Bhagwan Sharma; Neeta Singh; Sunesh Kumar Jain; Manu Goyal |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of human reproductive sciences Volume: 5 ISSN: 1998-4766 ISO Abbreviation: J Hum Reprod Sci Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-08-07 Completed Date: 2012-08-23 Revised Date: 2013-03-01 |
Medline Journal Info:
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Nlm Unique ID: 101473512 Medline TA: J Hum Reprod Sci Country: India |
Other Details:
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Languages: eng Pagination: 20-5 Citation Subset: - |
Affiliation:
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Department of Obstetrics and Gynecology, All India Institute of Medical Sciences (AIIMS), New Delhi, India. |
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