Document Detail


A prospective randomized study of pregnancy rates following intrauterine and intracervical insemination using frozen donor sperm.
MedLine Citation:
PMID:  2307249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cryopreserved sperm have lowered fertility when compared with fresh sperm in artificial insemination by donor programs. The purpose of this study was to compare pregnancy rates following intrauterine insemination (IUI) and intracervical insemination (ICI) with cryopreserved sperm in a prospective trial using the patient as her own control. A total of 154 patients were randomized into alternating treatment cycles and underwent 238 cycles of IUI and 229 cycles of ICI. The pregnancy rate per treatment cycle was 9.7% following IUI and 3.9% following ICI. Treatment outcome was influenced by patient age, ovulatory status, and endometriosis. Pregnancy success correlated well with the post-thaw survival of sperm and the number of motile cells inseminated. In spite of having normal semen parameters, some donors were found to have markedly reduced sperm fecundity. We conclude that IUI with cryopreserved sperm can be an effective treatment for couples with infertility, genetic indications, or other reasons.
Authors:
W Byrd; K Bradshaw; B Carr; C Edman; J Odom; G Ackerman
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Fertility and sterility     Volume:  53     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-04-06     Completed Date:  1990-04-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  521-7     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75235.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cell Survival / physiology
Cryopreservation
Female
Fertility
Humans
Insemination, Artificial / methods*
Insemination, Artificial, Heterologous / methods*
Male
Pregnancy
Pregnancy Outcome / epidemiology*
Prospective Studies
Spermatozoa / physiology
Comments/Corrections
Comment In:
Fertil Steril. 1991 Apr;55(4):850-1   [PMID:  2010018 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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