Document Detail

A prospective randomized study for postoperative pain relief of lower extremity fractures: efficacy of intrathecal morphine administration.
MedLine Citation:
PMID:  20942269     Owner:  NLM     Status:  MEDLINE    
Systemic opioids are known to be effective for controlling postoperative pain. Intrathecal morphine administration can be performed in a simple manner concurrently with spinal anesthesia. The purpose of this study was to investigate the efficacy of intrathecal morphine administration for the postoperative analgesia of lower extremity fractures. A prospective randomized study for postoperative pain relief was conducted. Fifty consecutive patients with a lower extremity fracture who underwent osteosynthesis under spinal anesthesia were enrolled. The patients were divided into two groups for comparative results. No baseline variable differences between the groups were observed. Twenty-two patients were assigned to a morphine group and were administered intrathecal bupivacaine combined with a single intrathecal injection of morphine. The other 28 patients were assigned to a control group and administered intrathecal bupivacaine alone. Pain intensity was assessed using the Visual Analog Scale (VAS). The use of supplemental analgesics, time of first request for supplemental analgesics, and side effects were investigated. During the initial 12 h after surgery, the VAS score was significantly lower in the morphine group (p < 0.05). The use of supplemental analgesic drugs was significantly less in the morphine group (p < 0.05). The time of first request of the control group was shorter than that of the morphine group (p < 0.001). Side effects were seen more frequently in the morphine group though there was no significant difference. Although the use of morphine requires appropriate postoperative care, an intrathecal morphine injection can be an attractive analgesic for the postoperative pain of lower extremity fractures.
Masaaki Machino; Yasutsugu Yukawa; Tetsuro Hida; Yoshiharu Oka; Teruo Terashima; Susumu Kinoshita; Fumihiko Kato
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Nagoya journal of medical science     Volume:  72     ISSN:  0027-7622     ISO Abbreviation:  Nagoya J Med Sci     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-10-14     Completed Date:  2010-11-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0412011     Medline TA:  Nagoya J Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  145-50     Citation Subset:  IM    
Department of Orthopedic Surgery, Chubu Rosai Hospital, Japan Labour Health and Welfare Organization, 1-10-6 Koumei, Minato-ku, Nagoya 455-8530, Japan.
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MeSH Terms
Analgesics, Opioid / administration & dosage*,  adverse effects
Fractures, Bone / surgery*
Injections, Spinal
Middle Aged
Morphine / administration & dosage*,  adverse effects
Pain, Postoperative / drug therapy*
Prospective Studies
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Analgesics, Opioid; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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