Document Detail

A prospective randomized study on oestradiol valerate supplementation in addition to intravaginal micronized progesterone in buserelin and HMG induced superovulation.
MedLine Citation:
PMID:  8458924     Owner:  NLM     Status:  MEDLINE    
A prospective randomized study was conducted to evaluate the use of adding oestradiol valerate 6 mg per os daily to intravaginal micronized progesterone (600 mg daily) as luteal supplements. The study comprised 378 infertile women superovulated with a gonadotrophin releasing-hormone agonist (GnRHa) and human menopausal gonadotrophins (HMG) for in-vitro fertilization (IVF) or zygote intra-Fallopian transfer (ZIFT). The clinical pregnancy rate was similar (29%) whether or not oestradiol valerate was added to intravaginal progesterone. Eighteen out of twenty-two endometrial biopsies were in phase, and morphological evaluations of the two luteal supplementation groups were not different. Serum hormone profiles in singleton pregnancies showed a similar day of appearance of human chorionic gonadotrophin (HCG) in both protocols but significantly lower oestradiol concentrations arose in the group without oestradiol valerate. In 32% of the singleton pregnancies, the first appearance of HCG occurred later than day 12 after HCG injection; in those ongoing pregnancies, corpus luteum rescue--as measured by significantly lower serum oestradiol and progesterone concentrations--was compromised. This study provided no evidence of any benefit of routinely supplementing GnRHa/HMG cycles with oestradiol valerate in addition to intravaginal micronized progesterone.
J Smitz; C Bourgain; L Van Waesberghe; M Camus; P Devroey; A C Van Steirteghem
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  8     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-04-23     Completed Date:  1993-04-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  40-5     Citation Subset:  IM    
Centre for Reproductive Medicine, Akademisch Ziekenhuis, Brussels, Belgium.
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MeSH Terms
Administration, Intravaginal
Buserelin / therapeutic use*
Clinical Protocols
Estradiol / analogs & derivatives*,  blood,  therapeutic use
Luteal Phase / blood
Menotropins / blood,  therapeutic use*
Ovulation Induction / methods*
Pregnancy Trimester, First / blood
Progesterone / administration & dosage*,  blood
Prospective Studies
Reg. No./Substance:
50-28-2/Estradiol; 57-83-0/Progesterone; 57982-77-1/Buserelin; 61489-71-2/Menotropins; 979-32-8/estradiol valerate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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