| A prospective randomized study of medications after silicone intubation. | |
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MedLine Citation:
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PMID: 8782256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: Following silicone intubation, most surgeons prescribe either an antibiotic or an antibiotic-steroid combination medication. No known controlled study has been performed to determine whether steroids in addition to antibiotics improve the postoperative outcome. PATIENTS AND METHODS: The author performed a prospective randomized study of 108 patients (118 eyes) who underwent silicone intubation over a period of 4 1/2 years. Sixty-seven patients received a combination of neomycin, polymyxin B, and dexamethasone and 41 patients received gentamicin for 2 weeks after surgery. A standardized surgical technique and instruments were used. Follow-up ranged from 8 to 44 months (average 19 months). RESULTS: No statistically significant difference was found in the failure rates when patients treated with an antibiotic-steroid combination were compared with those treated with antibiotic alone. CONCLUSION: Following silicone intubation, there appears to be no additional benefit of an antibiotic-steroid combination medication over an antibiotic alone. |
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Authors:
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D Liu |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Ophthalmic surgery and lasers Volume: 27 ISSN: 1082-3069 ISO Abbreviation: Ophthalmic Surg Lasers Publication Date: 1996 Jun |
Date Detail:
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Created Date: 1996-11-04 Completed Date: 1996-11-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9517132 Medline TA: Ophthalmic Surg Lasers Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 434-7 Citation Subset: IM |
Affiliation:
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University of Southern California, School of Medicine, Department of Ophthalmology, Doheny Eye Institute, Los Angeles, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Anti-Bacterial Agents / administration & dosage, therapeutic use* Child Child, Preschool Drug Combinations Female Fluprednisolone / administration & dosage, therapeutic use* Follow-Up Studies Gentamicins / administration & dosage, therapeutic use* Humans Intubation* Lacrimal Apparatus Diseases / therapy* Male Middle Aged Neomycin / administration & dosage, therapeutic use* Ophthalmic Solutions Polymyxin B / administration & dosage, therapeutic use* Postoperative Complications / prevention & control* Prospective Studies Silicone Elastomers* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Drug Combinations; 0/Gentamicins; 0/Ophthalmic Solutions; 0/Silicone Elastomers; 1404-04-2/Neomycin; 1404-26-8/Polymyxin B; 53-34-9/Fluprednisolone; 78666-15-6/Maxitrol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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