| A prospective randomized study: day 2 versus day 5 embryo transfer. | |
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MedLine Citation:
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PMID: 12042269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: This randomized controlled study was performed in an unselected IVF/ICSI population to test the hypothesis that blastocyst transfers result in higher clinical pregnancy rates (CPR) per oocyte retrieval when compared with day 2 transfers. METHODS: Blind randomization for transfer on day 2 (group 1) or day 5/6 (group 2) was performed before stimulation. Oocytes and embryos were cultured in sequential media in 5.5% CO(2), 5% O(2), 89.5% N(2) and 90% humidity. A maximum of two embryos was transferred. RESULTS: The two groups were similar for age, IVF indication, number of treatment cycles, rate of ICSI/IVF, number of fertilized oocytes and number of embryos transferred. The CPR/oocyte retrieval was comparable in group 1 (32%) and in group 2 (44%), while the CPR/embryo transfer was significantly higher (P < 0.01) in group 2 (60%) than in group 1 (35%). Similarly, the implantation rate per embryo transferred was significantly higher (P < 0.03) in group 2 (46%) than in group 1 (29%). The cryo-augmented delivery rate/oocyte retrieval was comparable in group 2 (36.3%) and in group 1 (28.6%). CONCLUSION: This randomized study in an unselected population showed a significantly higher CPR/embryo transfer and a tendency toward a higher CPR/oocyte retrieval in patients receiving blastocysts when compared with day 2 transfers. |
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Authors:
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Ingrid Van der Auwera; Sophie Debrock; Carl Spiessens; Hilde Afschrift; Els Bakelants; Christel Meuleman; Luc Meeuwis; Thomas M D'Hooghe |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 17 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-06-03 Completed Date: 2003-01-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 1507-12 Citation Subset: IM |
Affiliation:
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Leuven University Fertility Center, University Hospital Gasthuisberg, Catholic University Leuven, Herestraat 49, B-3000 Leuven, Belgium. Ingrid.Vanderauwera@pandora.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Embryo Transfer* Female Fertilization in Vitro Humans Pregnancy Prospective Studies Sperm Injections, Intracytoplasmic Time Factors |
| Comments/Corrections | |
Comment In:
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Hum Reprod. 2003 Apr;18(4):892-3; author reply 893
[PMID:
12660296
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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