| A prospective randomized study comparing misoprostol and oxytocin for premature rupture of membranes at term. | |
| | |
MedLine Citation:
|
PMID: 16753768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The aim of this randomized trial was to compare the efficacy and safety of vaginal misoprostol and oxytocin for cervical ripening and labor induction in patients with premature rupture of membrane (PROM) at term. METHODS: Ninety-seven women with PROM at term were assigned randomly to receive intravaginal misoprostol or oxytocin. The primary outcome measure was the induction-delivery interval. Secondary outcomes included the number of women who delivered vaginally within 12 hours of the start of the induction in the two groups, the cesarean, hyperstimulation, and failed induction rates, the mode of delivery, and the neonatal outcome. RESULTS: Forty-eight women were assigned to intravaginal misoprostol and 49 to oxytocin administration. The mean interval from induction to delivery was 10.61 +/- 2.45 hours in the misoprostol group and 11.57 +/- 1.91 hours in the oxytocin group (p = 0.063). The rates of vaginal delivery were 83.3% and 87.7% and cesarean delivery were 16.7% and 8.2% in the misoprostol and oxytocin groups, respectively. Neonatal outcomes were not significantly different. Of the cases, 8.3% in the misoprostol group and 8.2% in the oxytocin group revealed uterine contraction abnormalities. CONCLUSION: Our study demonstrates that, intravaginally, misoprostol results in a similar interval from induction of labor to delivery when compared to oxytocin. |
| | |
Authors:
|
Sahin Zeteroğlu; Yaprak Engin-Ustün; Yusuf Ustün; Mehmet Güvercinçi; Güler Sahin; Mansur Kamaci |
Related Documents
:
|
7326378 - Maternal positions in labor: analysis in relation to comfort and efficiency. 20173318 - Ultrasound in labor and delivery. 86468 - A comparative study of the efficiency of hydroxyprogesterone caproate and of chlormadin... 20486068 - Mode of delivery in women with antepartum fetal death and prior cesarean delivery. 17287108 - Intra-uterine growth retardation after prenatal administration of ginkgo biloba to rats. 2888208 - Comparison of maternal and fetal toxic dose responses in mammals. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: 19 ISSN: 1476-7058 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2006 May |
Date Detail:
|
Created Date: 2006-06-06 Completed Date: 2006-11-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: United States |
Other Details:
|
Languages: eng Pagination: 283-7 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Faculty of Medicine, Yüzüncü Yil University, Van, Turkey. sahinzeter@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Intravaginal Adult Cesarean Section / statistics & numerical data Delivery, Obstetric / statistics & numerical data Female Fetal Membranes, Premature Rupture / therapy* Gestational Age Humans Labor, Induced / methods* Misoprostol / administration & dosage*, adverse effects Oxytocics / administration & dosage*, adverse effects Oxytocin / administration & dosage*, adverse effects Pregnancy Pregnancy Outcome Prospective Studies Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Oxytocics; 50-56-6/Oxytocin; 59122-46-2/Misoprostol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of L-arginine on blood pressure in pregnancy-induced hypertension: a randomized placebo-contr...
Next Document: Fetal acidemia and electronic fetal heart rate patterns: is there evidence of an association?