| A prospective randomized safety trial of celecoxib for treatment of preterm labor. | |
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MedLine Citation:
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PMID: 12237643 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We compared the safety of celecoxib, a selective cyclo-oxygenase-2 inhibitor, with the safety of the nonselective cyclo-oxygenase inhibitor indomethacin, when it was administered for treatment of preterm labor. STUDY DESIGN: In a randomized, double-blind, placebo-controlled trial, 24 pregnant women in preterm labor at 24 to 34 weeks of gestation received either indomethacin or celecoxib for 48 hours. Clinical assessment, fetal sonography, and Doppler blood flow studies of the fetal ductus arteriosus were performed daily. RESULTS: Mean maximum ductal flow velocity was significantly elevated over baseline (82.9 +/- 4.6 cm/s vs 111.14 +/- 14.3 cm/s; P =.02) after 24 hours of indomethacin, but not celecoxib. Both medications were associated with a transient decrease in amniotic fluid volume, with a greater effect by indomethacin. The medications were equally effective in the maintenance of tocolysis. There were no significant maternal or neonatal adverse events. CONCLUSION: In this initial evaluation, the safety of short-term celecoxib in women with preterm labor was superior to that of indomethacin. |
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Authors:
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Catherine S Stika; Gilad A Gross; Gustavo Leguizamon; Susan Gerber; Roni Levy; Amit Mathur; Lisa M Bernhard; D Michael Nelson; Yoel Sadovsky |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 187 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-09-18 Completed Date: 2002-10-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 653-60 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Northwestern University, Chicago, Ill., USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cyclooxygenase Inhibitors / therapeutic use* Double-Blind Method Female Humans Indomethacin / adverse effects Obstetric Labor, Premature / drug therapy* Pregnancy Prospective Studies Pyrazoles Sulfonamides / adverse effects* Tocolytic Agents / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Cyclooxygenase Inhibitors; 0/Pyrazoles; 0/Sulfonamides; 0/Tocolytic Agents; 169590-42-5/celecoxib; 53-86-1/Indomethacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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