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A prospective randomized multicenter comparative study of BLM-240 (desflurane) versus sevoflurane in Japanese patients.
MedLine Citation:
PMID:  23224764     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The present study was conducted to evaluate the efficacy and safety of BLM-240 (desflurane) in comparison to sevoflurane in Japanese patients. A total of 216 patients were enrolled in this randomized comparative study at 15 medical institutions. The patients received either BLM-240 with 50-70 % N(2)O in O(2) (n = 111), BLM-240 with 30 % O(2) in air (n = 55), or sevoflurane with 50-70 % N(2)O in O(2) (n = 50). Efficacy was evaluated by an efficacy rate based on an efficacy evaluation criteria and recovery time to extubation from the discontinuation of the anesthetics. Safety was evaluated by incidence of adverse drug reactions (ADR) and other clinical indicators. The efficacy rate of BLM-240 was 98.8 % (164/166 patients), indicating that BLM-240 is effective as an anesthetic. Time from discontinuation of anesthetic delivery to extubation was 9.7 ± 0.6 min in the BLM-240/N(2)O group and 14.3 ± 0.9 min in the sevoflurane/N(2)O group, meeting the pre-defined non-inferiority criteria of BLM-240 to sevoflurane. There was no statistically significant difference in the incidence of total ADR between the BLM-240 group (62.0 %) and sevoflurane group (48.0 %). The results indicate that BLM-240 is an effective and safe inhalation anesthetic in Japanese patients.
Authors:
Junzo Takeda; Akiyoshi Namiki; Makoto Ozaki; Kazuhiko Fukuda; Kiyoshi Morita; Yuichi Kanmura; Michiaki Yamakage; Takami Komatsu; Eiichi Inada; Ryoichi Kawate; Masahiro Kanazawa; Atsuhiro Sakamoto; Shoichi Uezono; Shigehito Sato; Kimitoshi Nishiwaki; Yoshikazu Miyamoto; Hideki Nakatsuka; Nobuhiko Yasuda;
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-10
Journal Detail:
Title:  Journal of anesthesia     Volume:  -     ISSN:  1438-8359     ISO Abbreviation:  J Anesth     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8905667     Medline TA:  J Anesth     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Anesthesiology, School of Medicine, Keio University, 35 Shinano-machi, Shinjuku-ku, Tokyo, 160-8582, Japan, jtakeda@z3.keio.jp.
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