Document Detail


A prospective, randomized, multi-center trial to investigate Actovegin in prevention and treatment of acute oral mucositis caused by chemoradiotherapy for nasopharyngeal carcinoma.
MedLine Citation:
PMID:  20826029     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
PURPOSE: A multi-center prospective randomized trial was conducted to evaluate the efficacy and safety of Actovegin in the prevention and treatment of chemoradiotherapy-induced acute oral mucositis.
METHODS AND MATERIALS: Between February 2006 and May 2007, 156 evaluable patients with nasopharyngeal carcinoma were randomized to Group 1 (n=53) for prevention, Group 2 (n=51) for treatment, and Group 3 (n=52) for control. All patients received concomitant chemoradiotherapy ± induction chemotherapy. Radiation technique and dose were similar among 3 groups. Intravenous Actovegin of 30 ml daily (5 days/week) was administrated from day 1 of the radiotherapy for Group 1 and from the onset of grade 2 mucositis for Group 2, until the end of the radiotherapy.
RESULTS: The incidence of grade 3 mucositis was lower in Group 1 compared with Group 3 (26.4% vs. 55.8%, P=0.002). Group 2 had a lower progression rate of mucositis from grade 2 to 3 compared with Group 3 (39.2% vs. 60.4%, P=0.035). There was no difference in the onset time of grade 3 mucositis among 3 groups. Actovegin was well tolerated and no treatment-related adverse events were observed.
CONCLUSIONS: Actovegin is effective in the prevention and treatment of chemoradiotherapy-induced oral mucositis.
Authors:
Shao-Xiong Wu; Tian-Tian Cui; Chong Zhao; Jian-Ji Pan; Bing-Yu Xu; Ye Tian; Nian-Ji Cui
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Publication Detail:
Type:  Journal Article     Date:  2010-09-07
Journal Detail:
Title:  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology     Volume:  97     ISSN:  1879-0887     ISO Abbreviation:  Radiother Oncol     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8407192     Medline TA:  Radiother Oncol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  113-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Radiation Oncology, Cancer Center, Sun Yat-Sen University, Guangzhou, China. wushaox@mail.sysu.edu.cn
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