| A prospective, randomized, double-blind study comparing the efficacy of diltiazem, glyceryl trinitrate, and lidocaine for the treatment of anal fissure in children. | |
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MedLine Citation:
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PMID: 22212494 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: Anal fissure (AF) is a common perianal condition in children. Although adult patients with AF have been treated successfully using diltiazem, it has not been studied in children. The present randomized, prospective, double-blind study assessed the response, side effects, and recurrence of diltiazem. METHODS: Ninety-three children with AF were randomly divided into three groups. Each group received topical ointment. Group GTN received 0.2% glyceryl trinitrate, group L received 10% lidocaine, and group D received 2% diltiazem ointment. RESULTS: Eighty-two patients completed the 12-month study. At the end of the first 8-week course, the healing rate in group D was significantly higher than that of the other groups (p < 0.0001, χ (2) = 19.82). Nonresponders received a second course of the same treatment. Group D showed significantly higher healing rates than the other groups (p < 0.05, χ (2) = 7.227) at the end of the second 8-week course. The group D recurrence rate was significantly different than that of the other groups (p < 0. 002, χ ( 2 ) = 12.79). CONCLUSION: Diltiazem application is effective and safe for the treatment of AF in children, and has a low recurrence rate. The smooth dose-concentration curve causes minimal side effects. |
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Authors:
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Muazez Cevik; Mehmet Emin Boleken; Ibrahim Koruk; Servet Ocal; Mehmet Emin Balcioglu; Asim Aydinoglu; Cetin Ali Karadag |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-3 |
Journal Detail:
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Title: Pediatric surgery international Volume: - ISSN: 1437-9813 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8609169 Medline TA: Pediatr Surg Int Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Çocuk Cerrahisi Anabilim Dali, Harran Universitesi Tip Fakultesi, Morfoloji Binasi, Yenisehir Kampusu, 63300, Sanliurfa, Turkey, cevikmuazzez@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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