Document Detail

A prospective, randomized, double-blind study of the anesthetic efficacy of sodium bicarbonate buffered 2% lidocaine with 1:100,000 epinephrine in inferior alveolar nerve blocks.
MedLine Citation:
PMID:  20553136     Owner:  NLM     Status:  MEDLINE    
The authors, using a crossover design, randomly administered, in a double-blind manner, inferior alveolar nerve (IAN) blocks using a buffered 2% lidocaine with 1:100,000 epinephrine/sodium bicarbonate formulation and an unbuffered 2% lidocaine with 1:100,000 epinephrine formulation at 2 separate appointments spaced at least 1 week apart. An electric pulp tester was used in 4-minute cycles for 60 minutes to test for anesthesia of the first and second molars, premolars, and lateral and central incisors. Anesthesia was considered successful when 2 consecutive 80 readings were obtained within 15 minutes, and the 80 reading was continuously sustained for 60 minutes. For the buffered 2% lidocaine with 1:100,000 epinephrine/sodium bicarbonate formulation, successful pulpal anesthesia ranged from 10-71%. For the unbuffered 2% lidocaine with 1:100,000 epinephrine formulation, successful pulpal anesthesia ranged from 10-72%. No significant differences between the 2 anesthetic formulations were noted. The buffered lidocaine formulation did not statistically result in faster onset of pulpal anesthesia or less pain during injection than did the unbuffered lidocaine formulation. We concluded that buffering a 2% lidocaine with 1:100,000 epinephrine with sodium bicarbonate, as was formulated in the current study, did not statistically increase anesthetic success, provide faster onset, or result in less pain of injection when compared with unbuffered 2% lidocaine with 1:100,000 epinephrine for an IAN block.
Michael Whitcomb; Melissa Drum; Al Reader; John Nusstein; Mike Beck
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia progress     Volume:  57     ISSN:  0003-3006     ISO Abbreviation:  Anesth Prog     Publication Date:  2010  
Date Detail:
Created Date:  2010-06-17     Completed Date:  2010-09-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0043533     Medline TA:  Anesth Prog     Country:  United States    
Other Details:
Languages:  eng     Pagination:  59-66     Citation Subset:  D    
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MeSH Terms
Anesthesia, Dental / methods*
Anesthetics, Local / administration & dosage*
Dental Pulp Test
Double-Blind Method
Epinephrine / administration & dosage
Lidocaine / administration & dosage*
Mandibular Nerve
Nerve Block / methods*
Pain Measurement
Prospective Studies
Sodium Bicarbonate / administration & dosage*
Time Factors
Vasoconstrictor Agents / administration & dosage
Young Adult
Reg. No./Substance:
0/Anesthetics, Local; 0/Buffers; 0/Vasoconstrictor Agents; 137-58-6/Lidocaine; 144-55-8/Sodium Bicarbonate; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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