| A prospective randomized, controlled trial of intravenous versus oral iron for moderate iron deficiency anaemia of pregnancy. | |
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MedLine Citation:
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PMID: 20546462 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Iron deficiency anaemia is the most common deficiency disorder in the world, affecting more than one billion people, with pregnant women at particular risk. OBJECTIVES AND DESIGN: We conducted a single site, prospective, nonblinded randomized-controlled trial to compare the efficacy, safety, tolerability and compliance of standard oral daily iron versus intravenous iron. SUBJECTS: We prospectively screened 2654 pregnant women between March 2007 and January 2009 with a full blood count and iron studies, of which 461 (18%) had moderate IDA. Two hundred women matched for haemoglobin concentration and serum ferritin level were recruited. INTERVENTIONS: Patients were randomized to daily oral ferrous sulphate 250 mg (elemental iron 80 mg) with or without a single intravenous iron polymaltose infusion. RESULTS: Prior to delivery, the intravenous plus oral iron arm was superior to the oral iron only arm as measured by the increase in haemoglobin level (mean of 19.5 g/L vs. 12 g/L; P < 0.001); the increase in mean serum ferritin level (222 microg/L vs. 18 ug/L; P < 0.001); and the percentage of mothers with ferritin levels below 30 microg/L (4.5% vs. 79%; P < 0.001). A single dose of intravenous iron polymaltose was well tolerated without significant side effects. CONCLUSIONS: Our data indicate that intravenous iron polymaltose is safe and leads to improved efficacy and iron stores compared to oral iron alone in pregnancy-related IDA. |
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Authors:
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A Khalafallah; A Dennis; J Bates; G Bates; I K Robertson; L Smith; M J Ball; D Seaton; T Brain; J E J Rasko |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2010-05-19 |
Journal Detail:
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Title: Journal of internal medicine Volume: 268 ISSN: 1365-2796 ISO Abbreviation: J. Intern. Med. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-10 Completed Date: 2010-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904841 Medline TA: J Intern Med Country: England |
Other Details:
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Languages: eng Pagination: 286-95 Citation Subset: IM |
Affiliation:
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Launceston General Hospital (LGH), University of Tasmania, Tasmania, Australia. khalafallah@dhhs.tas.gov.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Anemia, Iron-Deficiency / blood, drug therapy* Birth Weight Drug Therapy, Combination Female Ferric Compounds / administration & dosage*, adverse effects Ferritins / blood Ferrous Compounds / administration & dosage*, adverse effects Hematinics / administration & dosage*, adverse effects Hemoglobins / metabolism Humans Infant, Newborn Infusions, Intravenous Patient Compliance Pregnancy Pregnancy Complications, Hematologic / blood, drug therapy* Prospective Studies Quality of Life Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Ferric Compounds; 0/Ferrous Compounds; 0/Hematinics; 0/Hemoglobins; 7720-78-7/ferrous sulfate; 79173-09-4/teferrol; 9007-73-2/Ferritins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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