Document Detail

A prospective randomized, controlled trial of intravenous versus oral iron for moderate iron deficiency anaemia of pregnancy.
MedLine Citation:
PMID:  20546462     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Iron deficiency anaemia is the most common deficiency disorder in the world, affecting more than one billion people, with pregnant women at particular risk. OBJECTIVES AND DESIGN: We conducted a single site, prospective, nonblinded randomized-controlled trial to compare the efficacy, safety, tolerability and compliance of standard oral daily iron versus intravenous iron. SUBJECTS: We prospectively screened 2654 pregnant women between March 2007 and January 2009 with a full blood count and iron studies, of which 461 (18%) had moderate IDA. Two hundred women matched for haemoglobin concentration and serum ferritin level were recruited. INTERVENTIONS: Patients were randomized to daily oral ferrous sulphate 250 mg (elemental iron 80 mg) with or without a single intravenous iron polymaltose infusion. RESULTS: Prior to delivery, the intravenous plus oral iron arm was superior to the oral iron only arm as measured by the increase in haemoglobin level (mean of 19.5 g/L vs. 12 g/L; P < 0.001); the increase in mean serum ferritin level (222 microg/L vs. 18 ug/L; P < 0.001); and the percentage of mothers with ferritin levels below 30 microg/L (4.5% vs. 79%; P < 0.001). A single dose of intravenous iron polymaltose was well tolerated without significant side effects. CONCLUSIONS: Our data indicate that intravenous iron polymaltose is safe and leads to improved efficacy and iron stores compared to oral iron alone in pregnancy-related IDA.
A Khalafallah; A Dennis; J Bates; G Bates; I K Robertson; L Smith; M J Ball; D Seaton; T Brain; J E J Rasko
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2010-05-19
Journal Detail:
Title:  Journal of internal medicine     Volume:  268     ISSN:  1365-2796     ISO Abbreviation:  J. Intern. Med.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-10     Completed Date:  2010-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  286-95     Citation Subset:  IM    
Launceston General Hospital (LGH), University of Tasmania, Tasmania, Australia.
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MeSH Terms
Administration, Oral
Anemia, Iron-Deficiency / blood,  drug therapy*
Birth Weight
Drug Therapy, Combination
Ferric Compounds / administration & dosage*,  adverse effects
Ferritins / blood
Ferrous Compounds / administration & dosage*,  adverse effects
Hematinics / administration & dosage*,  adverse effects
Hemoglobins / metabolism
Infant, Newborn
Infusions, Intravenous
Patient Compliance
Pregnancy Complications, Hematologic / blood,  drug therapy*
Prospective Studies
Quality of Life
Young Adult
Reg. No./Substance:
0/Ferric Compounds; 0/Ferrous Compounds; 0/Hematinics; 0/Hemoglobins; 7720-78-7/ferrous sulfate; 79173-09-4/teferrol; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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