Document Detail

A prospective, randomized comparison of vaginal misoprostol versus intra-amniotic prostaglandins for midtrimester termination of pregnancy.
MedLine Citation:
PMID:  16202734     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to compare the efficacy and adverse effects of vaginal misoprostol and intra-amniotic PGF2alpha for midtrimester abortion. STUDY DESIGN: One hundred thirty-two women between 12 and 24 weeks' gestation, seeking abortion in a tertiary hospital, were randomized to receive vaginal misoprostol (400 microg every 3 hours) or intra-amniotic PGF2alpha (carboprost 1.5 mg). Main outcome measures were induction-to-abortion interval, success rates at 24 and 48 hours, and adverse effects. RESULTS: Successful abortion rates at 24 and 48 hours between intra-amniotic PGF2alpha and vaginal misoprostol were not statistically different. However, vaginal misoprostol results in a significantly shorter mean induction-to-abortion interval, compared with intra-amniotic PGF2alpha (misoprostol: 16.2 hours; intra-amniotic PGF2alpha: 20.8 hours; P = .006), particularly among multiparous women (misoprostol: 13.1 hours; intra-amniotic PGF2alpha 18.3 hours; P = .011) and for gestation below 130 days (misoprostol: 14.6 hours; intra-amniotic PGF2alpha: 20.2 hours; P = .015). Fever and shivering were commoner with vaginal misoprostol. CONCLUSION: Vaginal misoprostol should be the regimen of choice for midtrimester abortion, particularly for multiparous women and women in the early second trimester.
Lin-Lin Su; Arijit Biswas; Mahesh Choolani; Vanaja Kalaichelvan; Kuldip Singh
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  193     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-05     Completed Date:  2006-01-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1410-4     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynaecology, National University Hospital, Singapore.
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MeSH Terms
Abortifacient Agents, Nonsteroidal / administration & dosage*
Abortion, Induced / methods*
Amniotic Fluid
Carboprost / administration & dosage*
Dinoprost / administration & dosage*
Misoprostol / administration & dosage*
Prospective Studies
Prostaglandins / administration & dosage*
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 0/Prostaglandins; 35700-23-3/Carboprost; 551-11-1/Dinoprost; 59122-46-2/Misoprostol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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