Document Detail


A prospective randomized longitudinal study involving 6 months of endurance or resistance exercise. Conduit artery adaptation in humans.
MedLine Citation:
PMID:  23247114     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Abstract  This randomized trial evaluated the impact of different exercise training modalities on the function and size of conduit arteries in healthy volunteers. Young (27 ± 5 years) healthy male subjects were randomized to undertake 6 months of either endurance training (ET; n = 10) or resistance training (RT; n = 13). High-resolution ultrasound was used to determine brachial, femoral and carotid artery diameter and wall thickness (IMT) and femoral and brachial flow-mediated dilatation (FMD) and glyceryl trinitrate (GTN)-mediated dilatation. Improvements in peak oxygen uptake occurred with ET (from 3.6 ± 0.7 to 3.8 ± 0.6 l min(-1), P = 0.024) but not RT. Upper body muscular strength increased following RT (from 57.8 ± 17.7 to 69.0 ± 19.5 kg, P < 0.001), but not ET. Both groups exhibited increases in lean body mass (ET, 1.4 ± 1.8 kg and RT, 2.3 ± 1.3 kg, P < 0.05). Resistance training increased brachial artery resting diameter (from 3.8 ± 0.5 to 4.1 ± 0.4 mm, P < 0.05), peak FMD diameter (+0.2 ± 0.2 mm, P < 0.05) and GTN-mediated diameter (+0.3 ± 0.3 mm, P < 0.01), as well as brachial FMD (from 5.1 ± 2.2 to 7.0 ± 3.9%, P < 0.05). No improvements in any brachial parameters were observed following ET. Conversely, ET increased femoral artery resting diameter (from 6.2 ± 0.7 to 6.4 ± 0.6 mm, P < 0.05), peak FMD diameter (+0.4 ± 0.4 mm, P < 0.05) and GTN-induced diameter (+0.3 ± 0.3 mm, P < 0.05), as well as femoral FMD-to-GTN ratio (from 0.6 ± 0.3 to 1.1 ± 0.8, P < 0.05). Resistance training did not induce changes in femoral artery parameters. Carotid artery IMT decreased in response to both forms of training. These findings indicate that 6 months of supervised exercise training induced changes in brachial and femoral artery size and function and decreased carotid artery IMT. These impacts of both RT and ET would be expected to translate to decreased cardiovascular risk.
Authors:
Angela L Spence; Howard H Carter; Louise H Naylor; Daniel J Green
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-12-17
Journal Detail:
Title:  The Journal of physiology     Volume:  591     ISSN:  1469-7793     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-08-21     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1265-75     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Adult
Analysis of Variance
Arteries / drug effects,  physiology*,  ultrasonography
Brachial Artery / physiology
Carotid Arteries / physiology
Carotid Intima-Media Thickness
Femoral Artery / physiology
Hemodynamics* / drug effects
Humans
Longitudinal Studies
Male
Muscle Contraction*
Muscle Strength
Muscle, Skeletal / physiology*
Nitroglycerin / pharmacology
Oxygen Consumption
Physical Endurance*
Prospective Studies
Resistance Training*
Time Factors
Vasodilation
Vasodilator Agents / pharmacology
Young Adult
Chemical
Reg. No./Substance:
0/Vasodilator Agents; G59M7S0WS3/Nitroglycerin
Comments/Corrections
Comment In:
J Physiol. 2013 Jun 1;591(Pt 11):2779-80   [PMID:  23729796 ]
J Physiol. 2013 May 1;591(Pt 9):2243-4   [PMID:  23740885 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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