Document Detail

A prospective randomised controlled study of patient-controlled propofol sedation in phobic dental patients.
MedLine Citation:
PMID:  10781117     Owner:  NLM     Status:  MEDLINE    
The safety and effectiveness of patient-controlled propofol sedation was prospectively assessed in 18 healthy, phobic dental patients. Using a randomised, crossover design each patient received two sessions of equivalent dental treatment under patient-controlled or clinician-controlled propofol sedation. The patient-controlled technique used 29.8% less drug (time-weighted dose) than the clinician-controlled method (p = 0.011). There was a high correlation between number of demands and number of doses actually infused during the patient-controlled technique (r = 0.99, p < 0. 001). Clinically, the level of sedation was lighter and the degree of operator satisfaction was higher with patient-controlled sedation. Blood pressure and arterial oxygen saturation showed minimal changes and remained within normal ranges during both techniques. Patient-controlled sedation produced a greater reduction in dental and general anxiety compared with clinician-controlled sedation, but the difference did not reach statistical significance. Three times the number of patients expressed a preference for the patient-controlled, compared with the clinician-controlled, technique. Patient-controlled sedation provides safe and acceptable intra-operative anxiolysis for phobic dental patients, but with reduced propofol dosage.
N M Girdler; D Rynn; J P Lyne; K E Wilson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  55     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-05-08     Completed Date:  2000-05-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  327-33     Citation Subset:  AIM; IM    
Department of Sedation, Newcastle Dental Hospital & School, Richardson Road, Newcastle upon Tyne NE2 4AZ, UK.
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MeSH Terms
Conscious Sedation / methods*
Cross-Over Studies
Dentistry, Operative*
Drug Administration Schedule
Hypnotics and Sedatives / therapeutic use*
Middle Aged
Phobic Disorders / drug therapy*
Propofol / therapeutic use*
Prospective Studies
Self Administration
Reg. No./Substance:
0/Hypnotics and Sedatives; 2078-54-8/Propofol
Comment In:
Anaesthesia. 2000 Sep;55(9):933   [PMID:  10947787 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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