Document Detail

A prospective patient observational study of the role of hyperhomocysteinemia in restenosis in patients undergoing infrainguinal angioplasty or bypass procedures.
MedLine Citation:
PMID:  17164744     Owner:  NLM     Status:  MEDLINE    
AIM: The aim of this study was to examine the correlation between elevated plasma homocysteine (HCy) and restenosis/occlusion in patients undergoing infrainguinal angioplasty or bypass grafting. METHODS: Fifty-three patients presenting to the Northern Vascular Unit were sequentially recruited to the study and prospectively followed up for 12 months post-infrainguinal angioplasty or bypass surgery. Plasma HCy was measured preprocedure and at least 3 months postprocedure using the Abbott IMx system. Hyperhomocysteinemia (HHCy) was taken at a level >15 microM/L. All patients were serially duplex scanned at 6 weeks, and 3, 6, 9 and 12 months. Kaplan-Meier analysis was performed to assess the restenosis/occlusion rate in patients with HHCy versus controls. Analysis of correlation between risk factors for restenosis/occlusion was performed using the Pearson correlation coefficient. In addition, logistic regression analysis was performed. RESULTS: Forty-eight percent of procedures was performed in patients with HHCy. There were 18 graft stenoses/occlusions, and 13 restenoses/occlusions postangioplasty. HHCy did not correlate with an increased risk of restenosis/occlusion (P=0.79). There was a significant correlation between HCy, age, folate and cholesterol levels. Logistic regression analysis revealed no factors that correlated with failure of therapeutic intervention. CONCLUSIONS: This study does not support the hypothesis that HHCy is associated with an increased risk of restenosis after vascular intervention.
M Hansrani; C Oates; G Stansby
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International angiology : a journal of the International Union of Angiology     Volume:  25     ISSN:  0392-9590     ISO Abbreviation:  Int Angiol     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-13     Completed Date:  2007-06-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8402693     Medline TA:  Int Angiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  378-84     Citation Subset:  IM    
Department of Surgery, Freeman Hospital, Newcastle upon Tyne, UK.
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MeSH Terms
Aged, 80 and over
Anastomosis, Surgical
Atherosclerosis / blood,  etiology*,  surgery*
Homocysteine / blood
Hyperhomocysteinemia / complications*
Middle Aged
Prospective Studies
Reg. No./Substance:

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