| A prospective, nonrandomized, open-labeled pilot study investigating the use of magnesium in patients undergoing nonacute percutaneous coronary intervention with stent implantation. | |
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MedLine Citation:
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PMID: 14506544 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Magnesium has recently been shown to inhibit acute stent thrombosis in animal models. This study tested the feasibility of magnesium administration in patients undergoing nonacute percutaneous coronary intervention with stent implantation. METHODS: Twenty-one patients undergoing nonemergent percutaneous coronary intervention were enrolled and received intravenous magnesium sulfate (2-g bolus over 20 minutes prepercutaneous coronary intervention, followed by 14 g over 12 hours infusion). Endpoints: safety outcomes--hypotension, bradycardia, bleeding complications and heart block within first 24 hours; angiographic outcomes--acute thrombotic occlusion and need for platelet glycoprotein IIb/IIIa inhibitor bailout; and clinical outcomes--death, myocardial infarction, recurrent ischemia, and need for urgent revascularization at 48 hours and 30 days. RESULTS: No significant effects on heart rate or blood pressure, major bleeding complication, or new electrocardiographic changes were observed. Angiographic thrombus was visualized in two cases, and coronary artery dissection in one case poststent deployment. None of these cases required the use of glycoprotein inhibitors for bailout. Death, myocardial infarction, recurrent ischemia, and need for urgent revascularization were not observed. The serum magnesium level increased from 2.1 +/- 0.3 mg/dL at baseline to 3.5 +/- 0.8 mg/dL at the end of the infusion (P <.0001). Platelet activation was significantly inhibited at the end of the magnesium sulfate infusion. CONCLUSION: Intravenous magnesium sulfate has been demonstrated as a feasible and safe agent in patients undergoing nonacute percutaneous coronary intervention with stent implantation. A randomized clinical trial comparing magnesium with glycoprotein inhibitors during percutaneous coronary intervention is warranted. |
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Authors:
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Vladimir Rukshin; Raul Santos; Mitch Gheorghiu; Prediman K Shah; Saibal Kar; Sriram Padmanabhan; Babak Azarbal; Vivian T Tsang; Raj Makkar; Bruce Samuels; Norman Lepor; Ivor Geft; Steve Tabak; Mehran Khorsandhi; Neil Buchbinder; Neil Eigler; Bojan Cercek; Keta Hodgson; Sanjay Kaul |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiovascular pharmacology and therapeutics Volume: 8 ISSN: 1074-2484 ISO Abbreviation: J. Cardiovasc. Pharmacol. Ther. Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-09-24 Completed Date: 2003-12-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9602617 Medline TA: J Cardiovasc Pharmacol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 193-200 Citation Subset: IM |
Affiliation:
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Burns and Allen Research Institute, Department of Medicine, Cedars-Sinai Medical Center, and UCLA School of Medicine, Los Angeles, California, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Transluminal, Percutaneous Coronary* Coronary Angiography Coronary Disease / blood, radiography, therapy Coronary Thrombosis / etiology, prevention & control* Drug Administration Schedule Electrocardiography Humans Infusions, Intravenous Magnesium Sulfate / administration & dosage, therapeutic use* Male Middle Aged Pilot Projects Platelet Aggregation / drug effects Prospective Studies Stents* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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7487-88-9/Magnesium Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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